Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Principles of c-di-GMP signalling in bacteria.
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A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
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Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
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Journal Article
Ca2+ inhibition of beta-adrenergic receptor- and forskolin-stimulated cAMP accumulation in C6-2B rat glioma cells is independent of protein kinase C.
TL;DR: Data provide compelling evidence that increases in intracellular free Ca2+ concentration without activation of protein kinase C suffice and are responsible for the inhibition of cAMP accumulation in C6-2B cells.
Journal ArticleDOI
Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function.
Richard A. Bundey,Paul A. Insel +1 more
TL;DR: It is demonstrated that adenoviral-mediated gene transfer of AC6 in human umbilical vein endothelial cells preferentially enhances prostacyclin receptor (versus other GPCR)-stimulated cAMP synthesis and, in parallel, inhibits thrombin-stimulated increases in endothelial cell barrier function.
Journal ArticleDOI
Gαq-coupled receptor signaling enhances adenylate cyclase type 6 activation
Michael A. Beazely,Val J. Watts +1 more
TL;DR: The hypothesis that Gα q -coupled receptor-mediated calcium signaling potentiates AC6 activation in intact cells is supported.
Journal ArticleDOI
Changes in pH sensitivity of adenylate cyclase specifically induced by fluoride and vanadate.
TL;DR: The data suggested that combinations of pH, divalent cation, and activating ligand dictate the interactions of the constitutive subunits of the adenylate cyclase and provide additional criteria with which current models for the regulation of the enzyme may be tested.
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