Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Journal ArticleDOI
Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases
TL;DR: Evidence is evaluated for regulation of adenylyl cyclases (ACs) by Ca(2+)-signaling pathways, with an emphasis on verification of this regulation in a physiological context, and major gaps are apparent in the interactions that have been assumed.
Book ChapterDOI
G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains.
TL;DR: This review focuses on the properties of lipid rafts and caveolae, the mechanisms by which they localize signaling molecules and the identity of GPCR signaling components that are organized in these domains.
Journal ArticleDOI
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling.
Jason Z. Zhang,Tsan-Wen Lu,Lucas M. Stolerman,Brian Tenner,Jessica Yang,Jin Fan Zhang,Martin Falcke,Martin Falcke,Padmini Rangamani,Susan S. Taylor,Sohum Mehta,Jin Zhang +11 more
TL;DR: It is revealed that the type I regulatory subunit of cAMP-dependent protein kinase (PKA), RIα, undergoes liquid-liquid phase separation (LLPS), critical for effective cAMP compartmentation.
Journal ArticleDOI
International union of basic and clinical pharmacology. CI. structures and small molecule modulators of mammalian adenylyl cyclases
TL;DR: Understanding of the (patho)physiology of AC isoforms and the development of clinically useful drugs targeting ACs is still in its infancy, in contrast to the guanylyl cyclase field.
Journal ArticleDOI
Store-operated cyclic AMP signalling mediated by STIM1.
Konstantinos Lefkimmiatis,Meera Srikanthan,Isabella Maiellaro,Isabella Maiellaro,Mary Pat Moyer,Silvana Curci,Aldebaran M. Hofer +6 more
TL;DR: A pathway is proposed in which the content of internal Ca2+ stores is directly connected to cAMP signalling through a process that involves STIM1, which resulted in enhanced cAMP accumulation and PKA activation, measured using FRET-based cAMP indicators.
References
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