Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Principles of c-di-GMP signalling in bacteria.
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A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
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Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
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Journal ArticleDOI
Altered Stress-Induced Anxiety in Adenylyl Cyclase Type VIII-Deficient Mice
Michele L. Schaefer,Scott T. Wong,David F. Wozniak,Lisa M. Muglia,Jason Liauw,Min Zhuo,A. Nardi,Richard E. Hartman,Sherri K. Vogt,Christina Luedke,Daniel R. Storm,Louis J. Muglia +11 more
TL;DR: A novel role for AC8 in the modulation of anxiety is demonstrated as a compromise in calcium-stimulated AC activity in the hippocampus, hypothalamus, thalamus, and brainstem and the behavioral consequences of AC8 deficiency are evaluated.
Journal ArticleDOI
Biochemical studies of stimulus convergence during classical conditioning in Aplysia: dual regulation of adenylate cyclase by Ca2+/calmodulin and transmitter
TL;DR: The dependence of cyclase activation on the temporal pattern of Ca2+ and transmitter addition is explored and it is suggested that the dually regulated adenylate cyclase might underlie the temporal requirements for effective classical conditioning in this system.
Journal ArticleDOI
Regulation of adenylyl cyclase from Paramecium by an intrinsic potassium conductance
Joachim E. Schultz,Susanne Klumpp,Roland Benz,Wilhelm J. Ch. Schürhoff-Goeters,Angela Schmid +4 more
TL;DR: A hyperpolarization-activated K+ efflux appears to directly regulate adenylyl cyclase activity in vivo, and is associated with secondary function as carrier of the K+ resting conductance.
Journal ArticleDOI
Capacitative Ca2+ entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. Evidence that physiologically evoked Ca2+ entry regulates Ca(2+)-inhibitable adenylyl cyclase in non-excitable cells.
TL;DR: It is demonstrated not only that Ca2+ entry mediates the inhibitory effects of Ca2+, but also that diffuse elevations in [Ca2+]i are ineffective in modulating cAMP synthesis, which suggests that, as with certain Ca(2+)-sensitive ion channels, Ca(1-)-sensitive adenylyl cyclases may be functionally colocalized with Ca2- entry channels.
Journal ArticleDOI
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.
TL;DR: The ability of phorbol ester to increase basal and isoproterenol-stimulated type VII activity appears to be a direct effect on this adenylyl cyclase isoform and not the result of modification of the inhibitory G protein, Gi.
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