Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
More filters
Journal ArticleDOI
Principles of c-di-GMP signalling in bacteria.
TL;DR: This Review focuses on emerging principles of c-di-GMP signalling using selected systems in different bacteria as examples.
Journal ArticleDOI
A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
TL;DR: Evidence is examined that forms the basis of this coupled-clock system concept in cardiac SANCs, where G protein-coupled receptors signaling creates pacemaker flexibility, ie, effects changes in the rhythmic action potential firing rate, by impacting on these very same factors that regulate robust basal coupled- clock system function.
Journal ArticleDOI
Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
TL;DR: The role of Caveolae/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target are reviewed.
Journal ArticleDOI
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
TL;DR: Genes for these important regulatory enzymes are linked to schizophrenia, stroke and asthma, thus indicating the therapeutic potential that selective inhibitors could have as anti-inflammatory, anti-depressant and cognitive enhancer agents.
Journal ArticleDOI
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
More filters
Journal ArticleDOI
Calcineurin Feedback Inhibition of Agonist-evoked cAMP Formation
Ferenc A. Antoni,Richard J. O. Barnard,Michael J. Shipston,S. M. Smith,James Simpson,Janice M. Paterson +5 more
TL;DR: Analysis of cAMP production revealed that intracellular Ca derived through voltage-regulated calcium channels reduces cAMP formation induced by corticotropin releasing-factor or β-adrenergic stimulation and that this effect of Ca is inhibited by blockers of calcineurin.
Journal Article
Ca(2+)-sensitive adenylyl cyclases.
Journal Article
Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels in cardiac myocytes.
TL;DR: It is demonstrated that increased entry of Ca2+ via L-type calcium channels in response to beta-adrenergic receptor stimulation acts as a negative regulator of the effect of beta receptor stimulation on adenylyl cyclase activity.
Journal ArticleDOI
Cyclic GMP diffusion coefficient in rod photoreceptor outer segments.
TL;DR: The truncated rod outer segment preparation from bullfrog and tiger salamander and the estimated diffusion coefficient is the same at high and low concentrations of cGMP, suggesting no significant effect from buffering over these concentration ranges.
Related Papers (5)
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Manuela Zaccolo,Tullio Pozzan +1 more
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
Marco Conti,Joseph A. Beavo +1 more