Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells.
Marcel M. G. J. van Borren,Marcel M. G. J. van Borren,Arie O. Verkerk,Ronald Wilders,Najat Hajji,Jan G. Zegers,Jan Bourier,Hanno L. Tan,E. E. Verheijck,Stephan L. M. Peters,Astrid E. Alewijnse,Jan-Hindrik Ravesloot +11 more
TL;DR: Functional evidence is provided for the contribution of the Cai2+ transient to ACh-induced inhibition of pacemaker activity and cAMP content in rabbit SAN cells and muscarinic receptor stimulation inhibits theCai2- transient via a cAMP-dependent signaling pathway.
Journal ArticleDOI
cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels
TL;DR: Data indicate that the up-regulation of voltage-gated L-type Ca2+-channels and early electrical excitability are critical steps in the cAMP-dependent differentiation of SVZ-derived NPCs into functional neurons.
Journal ArticleDOI
Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits.
Stefania Averaimo,Stefania Averaimo,Stefania Averaimo,Xavier Nicol,Xavier Nicol,Xavier Nicol +5 more
TL;DR: Focusing on neuronal polarization, neurotransmitter specification, axon guidance, and refinement of neuronal connectivity, the recent advances in understanding the features of cAMP signals and their dynamic interactions with calcium and cGMP involved in shaping the nervous system are summarized.
Journal ArticleDOI
Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting.
Vaishnav Krishnan,Ami Graham,Michelle S. Mazei-Robison,Diane C. Lagace,Kyoung Shim Kim,Shari G. Birnbaum,Amelia J. Eisch,Pyung Lim Han,Daniel R. Storm,Venetia Zachariou,Venetia Zachariou,Eric J. Nestler +11 more
TL;DR: Data illustrate the complex manner in which Ca(2+)/calmodulin-stimulated ACs contribute to emotional behavior and support the possibility that a selective AC5 antagonist would be of therapeutic value against depression and anxiety disorders.
Journal ArticleDOI
cAMP signaling microdomains and their observation by optical methods.
TL;DR: The optical methods used for monitoring cAMP and protein kinase A (PKA) signaling in living cells are reviewed, providing some examples of their application in neurons, and the major hypotheses on the formation of cAMP/PKA microdomains are discussed.
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