Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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PLCδ: Johnny-come-lately to ORAI and the ups and downs of calcium signalling
TL;DR: Ca2+ selective store-independent arachidonate-regulated Ca2+ (ARC) channel turned out to be regulated by STIM1 and encoded by heteromultimers of Orai1 and ORAi3 (Shuttleworth, 2009).
Journal ArticleDOI
Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling
TL;DR: CD AC4 does not play a role in the physiologic regulation of CD Na and water handling, and there were no differences in plasma AVP or plasma renin concentration between CD AC4 KO and control mice.
Journal ArticleDOI
Interferon-gamma inhibits adenosine A2A receptor function in hepatic stellate cells by STAT1-mediated repression of adenylyl cyclase.
Eric T Block,Bruce N. Cronstein +1 more
TL;DR: IFNγ inhibits the function of the adenosine A2A receptor in hepatic stellate cells by downregulating the expression of adenylyl cyclase, which explains, at least in part, the protective effect of IFNγ in hepatatic fibrosis.
Journal ArticleDOI
Gsα stimulation of mammalian adenylate cyclases regulated by their hexahelical membrane anchors.
TL;DR: It is reported that Gsα stimulation of human AC isoforms 2, 3, 5, and 9 expressed in Sf9 cells is inhibited by serum as is AC activity in membranes isolated from rat brain cortex, and a mechanistic three state model of AC regulation is presented compatible with all known regulatory inputs into mammalian ACs.
Journal ArticleDOI
Molecular context of Schistosoma mansoni transmission in the molluscan environments: A mini-review.
TL;DR: This paper presents a concise exposition of the cellular, biochemical, genetic and immunological dynamics of the complex and statge-by-stage interactions between the parasite and its vector in their aquatic environment and highlights the possible crosstalk between the parasites' intracellular cyclic adenosine monophosphate and p38 mitogen-activated protein kinase during the intramolluscan stage.
References
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