Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
More filters
Journal ArticleDOI
Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.
TL;DR: The present study shows that stimulation of AC2 by pharmacological activation of PKC or muscarinic receptor activation is primarily the result of phosphorylation of Ser490 and Ser543, as opposed to the previously proposed Thr1057, and underline the sophisticated regulatory capacities ofAC2, in not only being subject to regulation by PKC, but also and in an opposite manner to Gβγ subunits, depending on their source.
Journal ArticleDOI
Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth
TL;DR: A review of the available data regarding NCAM-induced intracellular signaling and focus on the most intensively studied cellular response, neurite outgrowth, is presented in this article.
Journal ArticleDOI
Activation of the cyclic AMP pathway promotes serotonin-induced Ca2+ oscillations in salivary glands of the blowfly Calliphora vicina.
TL;DR: The results suggest that activation of the cyclic AMP pathway promotes the generation of 5-HT-induced Ca(2+) oscillations in blowfly salivary glands.
Journal ArticleDOI
Treatments for diabetes mellitus type II: New perspectives regarding the possible role of calcium and cAMP interaction.
Diego Soares Carvalho,Alexandre Aparecido de Almeida,Aurélio Ferreira Borges,Diego Vannucci Campos +3 more
TL;DR: It is proposed that pharmacological manipulation of the Ca2+/cAMP interaction system could lead to important targets for pharmacological improvement of insulin secretion in DM type 2.
Journal ArticleDOI
Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens
Guillermo Aquino-Miranda,Juan Escamilla-Sánchez,Raúl González-Pantoja,Antonio Bueno-Nava,José-Antonio Arias-Montaño +4 more
TL;DR: The results indicate that in rNAcc H3Rs do not modulate dopamine uptake or release, but regulate dopamine synthesis by inhibiting cAMP formation and thus PKA activation.
References
More filters
Journal ArticleDOI
Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
Journal ArticleDOI
Store-operated calcium channels.
Anant B. Parekh,James W. Putney +1 more
TL;DR: The key electrophysiological features of I(CRAC) and other store-operated Ca(2+) currents and how they are regulated are described, and recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca( 2+) entry pathway are considered.
Journal ArticleDOI
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
TL;DR: This article reviews many of the more important aspects about the structure, cellular localization, and regulation of each family of phosphodiesterases and places particular emphasis on new information obtained in the last few years about how differential expression andregulation of individual phosphodiesters relate to their function(s) in the body.
Journal ArticleDOI
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
TL;DR: Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with G TP, and this theory may apply generally to membrane signal transduction involving surface receptors.
Journal ArticleDOI
Lipid Rafts: Elusive or Illusive?
TL;DR: There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids, and it seems that a definitive proof of raft existence has yet to be obtained.
Related Papers (5)
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Manuela Zaccolo,Tullio Pozzan +1 more
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
Marco Conti,Joseph A. Beavo +1 more