Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
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References
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Journal ArticleDOI
Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase.
TL;DR: These findings demonstrate that both PKA and PP2A are integral components of the class C L-type Ca2+ channel that determine the phosphorylation level of serine 1928 and thereby channel activity.
Journal ArticleDOI
The calmodulin binding domain of nitric oxide synthase and adenylyl cyclase
TL;DR: The highest affinity cal modulin binding site of the calmodulin-dependent adenylyl cyclase was assigned to peptide AC-28 (amino acids 495-522) by titration with dansylcalmodulin and by the ability to inhibit the calModulin-stimulated activity of purified calmodul- Stimulated adenyll cyclase.
Journal ArticleDOI
Type-specific Regulation of Adenylyl Cyclase SELECTIVE PHARMACOLOGICAL STIMULATION AND INHIBITION OF ADENYLYL CYCLASE ISOFORMS
Takeshi Onda,Yoko Hashimoto,Masashi Nagai,Hiroshi Kuramochi,Saito Seiichi,Hiroko Yamazaki,Yoshiyuki Toya,Ikuko Sakai,Charles J. Homcy,Kiyohiro Nishikawa,Yoshihiro Ishikawa,Yoshihiro Ishikawa +11 more
TL;DR: The data suggest the feasibility of adenylyl cyclase isoform-targeted regulation of cyclic AMP signaling by pharmacological reagents, either alone or in combination.
Journal ArticleDOI
Functional Co-localization of Transfected Ca2+-stimulable Adenylyl Cyclases with Capacitative Ca2+ Entry Sites
TL;DR: Three adenylyl cyclases were heterologously expressed in HEK 293 cells, and conditions were devised that distinguished capacitative Ca2+ entry from both internal release and nonspecific elevation in [Ca2+]i around the plasma membrane, suggesting a quite unsuspected, essential association of Ca2+.
Journal ArticleDOI
Bicarbonate-responsive soluble adenylyl cyclase defines a nuclear cAMP microdomain
Jonathan H. Zippin,Jeanne Farrell,David R Huron,Margarita Kamenetsky,Kenneth C. Hess,Donald A. Fischman,Lonny R. Levin,Jochen Buck +7 more
TL;DR: The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
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