Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
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CATALYTIC RECEPTORS: Catalytic receptors
TL;DR: The Fifth Edition of the ‘Guide to Receptors and Channels’ is a compilation of the major pharmacological targets divided into seven sections, presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside suggestions for further reading.
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Glutamate Differently Modulates Metabotropic Glutamate Receptors in Neuronal and Glial Cells
Carlos Alberto Castillo,David León,Inmaculada Ballesteros-Yáñez,Inmaculada Iglesias,Mairena Martín,José Luis Albasanz +5 more
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Luigi Sapio,Michela Illiano,Antonietta Esposito,Emilio Chiosi,Annamaria Spina,Silvio Naviglio +5 more
TL;DR: Some features of cAMP/PKA signaling that are relevant to cancer biology are highlighted and an update on targeting PKA in cancer therapy is presented.
Caveolae as Organizers of Pharmacologically Relevant
TL;DR: The role of Caveolae/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target are reviewed.
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Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target
Christoffer Mertz,Sara Krarup,Cecilie D. Jensen,Sandy E. H. Lindholm,Christina Kjær,Lars H. Pinborg,Lasse K. Bak +6 more
TL;DR: This review explores selected aspects of cAMP signaling in the context of epileptogenesis and seizures including cAMP response element binding (CREB)-mediated transcriptional regulation and argues that targeting upstream cAMP signals might be more fruitful than targeting CREB itself.
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