Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
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Spatiotemporal control of cyclic AMP immunomodulation through the PKA–Csk inhibitory pathway is achieved by anchoring to an Ezrin–EBP50–PAG scaffold in effector T cells
Isabelle Cornez,Kjetil Taskén +1 more
TL;DR: A variety of immunoregulatory signals to effector T cells from monocytes, macrophages and regulatory T cells act through cyclic adenosine monophosphate, which modulates directly the proximal events that take place after engagement of the T cell receptor.
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In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
Angela McCahill,Lachlan Campbell,Theresa McSorley,Arvind Sood,Martin J. Lynch,Xiang Li,Chen Yan,George S. Baillie,Miles D. Houslay +8 more
TL;DR: It is suggested that increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for Pde4A10 in cardiac myocytes.
Journal ArticleDOI
Adenylyl cyclases in the digestive system.
TL;DR: The basic structure, regulation and physiological roles of ACs in the digestive system are discussed and two transmembrane AC isoforms activated by Gαs are discussed.
Journal ArticleDOI
Cyclic AMP accelerates calcium waves in pancreatic acinar cells
Ahsan U. Shah,Wayne M. Grant,Sahibzada U. Latif,Zahir M. Mannan,Alexander Park,Sohail Z. Husain +5 more
TL;DR: Data suggest that cAMP accelerates the speed of the Ca(2+) wave in pancreatic acinar cells, and a likely target of this modulation is the RyR, and these effects are mediated independently by PKA and Epac pathways.
Journal ArticleDOI
The role of osteocytes-specific molecular mechanism in regulation of mechanotransduction - A systematic review.
TL;DR: A systematic review of osteocyte-related pathways and signaling molecules during mechanotransduction is presented in this article, which provides an up-to-date insight to different steps of different steps.
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