Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Journal ArticleDOI
PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes.
TL;DR: PKA-dependent βAR-to-HCN signaling does not result from cAMP insensitivity of sinoatrial HCN channels and might instead arise via PKA- dependent limitation of cAMP production and/or cAMP access to HCn channels in SAMs.
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Second messenger networks for accurate growth cone guidance.
TL;DR: This review examines how signal specification and amplification can be achieved inside the growth cone by multiple second messenger signaling pathways activated downstream of guidance cues, including the calcium ion, cyclic nucleotide, and phosphatidylinositol signaling pathways.
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HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse.
TL;DR: The results indicate that HIV-1 exploits the interconnectivity among vesicle traffic, Ca2+ membrane territories, and signaling nanoclusters to modulate T cell signaling and function.
Journal ArticleDOI
Adenylyl cyclase/cAMP-PKA-mediated phosphorylation of basal L-type Ca(2+) channels in mouse embryonic ventricular myocytes.
Xisheng Yan,Shijun Gao,Ming Tang,Jiaoya Xi,Linlin Gao,Minjie Zhu,Hongyan Luo,Xinwu Hu,Yunjie Zheng,Jürgen Hescheler,Huamin Liang +10 more
TL;DR: The high basal level of LTCC phosphorylation is due to the high intrinsic PKA activity and the high intrinsically AC activity at EDS, possibly owing to the little or no effect of Ca(2+) influx via LTCCs on AC activity, leading to the inability to inhibit AC.
Book ChapterDOI
Ca(2+) signalling by IP(3) receptors.
Colin W. Taylor,David L. Prole +1 more
TL;DR: The assembly of IP(3)R into clusters are key features that allow IP(4,4,5-trisphosphate-induced signals to be delivered locally to specific target proteins or more globally to the entire cell.
References
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