Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
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Dissertation
Etude du signal AMP cyclique déclenché par la chimiokine CX3CL1 en aval de son récepteur CX3CR1
TL;DR: The role of AMPc on CX3CL1/CX3CR1 is investigated in this article, where it is shown that it can inhibit l'enzyme de synthese de l'AMP cyclique (AMPc), l'adenylate cyclase, and l'adhesion.
Journal ArticleDOI
Analysis of the source of aggressiveness in gamecocks.
TL;DR: The evolutionary analysis indicated that the ADRβ2 (T44I and Q232R) mutations were heritable in all Galliformes, whereas the T440N mutation of ADRα1D and V296I mutations ofADRα2A were unique to Shamo and originated by artificial selection.
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Heterologous, PKC-Mediated Desensitization of Human Histamine H3 Receptors Expressed in CHO-K1 Cells
Wilber Montejo-López,Nayeli Rivera-Ramírez,Juan Escamilla-Sánchez,Ubaldo García-Hernández,José-Antonio Arias-Montaño +4 more
TL;DR: Results indicate that the human histamine H3 receptor of 445 amino acids undergoes heterologous desensitization upon activation of receptors coupled to PKC stimulation.
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Potential role of adenylyl cyclase 8 signaling complexes in regulating insulin secretion from pancreatic beta cells.
Ida Lønsmann,Lasse K. Bak +1 more
TL;DR: It is suggested that disrupting the protein-protein interaction between PKA-anchoring protein 79 (AKAP79) and AC8 could lead to disinhibition of AC8 activity and increased insulin secretion, and potentially, AC8 protein interactions could become a future target in type 2 diabetic patients with dysfunction of insulin secretion.
References
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Kai Simons,Derek Toomre +1 more
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Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
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The role of hormone receptors and GTP-regulatory proteins in membrane transduction
TL;DR: Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with G TP, and this theory may apply generally to membrane signal transduction involving surface receptors.
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Lipid Rafts: Elusive or Illusive?
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