Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
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Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion
Min Goo Lee,Ehud Ohana,Ehud Ohana,Ehud Ohana,Hyun Woo Park,Dongki Yang,Dongki Yang,Dongki Yang,Shmuel Muallem,Shmuel Muallem,Shmuel Muallem +10 more
TL;DR: The molecular mechanism of fluid and HCO(3)(-) secretion by the pancreas and salivary glands is focused on to highlight the similarities of the fundamental mechanisms of acinar and duct cell functions, and to point out the differences to meet gland-specific secretions.
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Store-operated CRAC channels: function in health and disease
TL;DR: Recent advances in understanding the gating and function of CRAC channels, their links to human disease and key issues for the development of channel blockers are summarized.
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IP3 Receptors: Toward Understanding Their Activation
Colin W. Taylor,Stephen C. Tovey +1 more
TL;DR: It is suggested that interactions of critical phosphate groups in IP(3) with opposite sides of the clam-like IP( 3)-binding core cause it to close and propagate a conformational change toward the pore via the adjacent N-terminal suppressor domain.
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Adenylyl Cyclase–A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling
TL;DR: The ability of AKAPs to assemble intricate feedback loops to control spatiotemporal aspects of cAMP signaling adds yet another dimension to the classic cAMP pathway.
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The Prostanoid EP4 Receptor and Its Signaling Pathway
TL;DR: The aim of this review is to present current findings on the biologic functions of the EP4 receptor and discuss its diversity from the standpoint of EP4-mediated signaling.
References
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