Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Principles of c-di-GMP signalling in bacteria.
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A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
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Nicotinic acetylcholine receptor α7 regulates cAMP signal within lipid rafts
Jin Oshikawa,Yoshiyuki Toya,Takayuki Fujita,Masato Egawa,Jun-ichi Kawabe,Satoshi Umemura,Yoshihiro Ishikawa +6 more
TL;DR: It is shown that the nAChR α7-subunit has a property of high Ca2+ permeability and may have specific fun...
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Voltage-sensitive adenylyl cyclase activity in cultured neurons. A calcium-independent phenomenon.
TL;DR: It is reported that adenylyl cyclase activity in cerebellar neurons is synergistically stimulated by depolarizing agents and β-adrenergic receptor activation, and it is hypothesized that conformational changes in the catalytic subunit of the enzymes caused by change in the membrane potential may enhance stimulation of adenyll cyclases by the guanylyl nucleotide stimulatory protein.
Journal ArticleDOI
Novel Regulatory Properties of Human Type 9 Adenylate Cyclase
Medhane G. Cumbay,Val J. Watts +1 more
TL;DR: It is reported that quinpirole activation of the inhibitory G protein-coupled D2L dopamine receptor inhibits Gαs stimulation of AC9, and the first evidence for regulation of AC 9 by protein kinase C (PKC) is reported.
Journal ArticleDOI
Multiple defects in the activity of adenylate cyclase from the Drosophila memory mutant rutabaga.
Yadin Dudai,Shoshana Zvi +1 more
TL;DR: It is suggested that rutabaga is lesioned in a subpopulation, or a functional state, of adenylate cyclase, which may play a role in memory formation.
Journal ArticleDOI
β-Adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor
Sunita Warrier,Andriy E. Belevych,Monica Ruse,Richard L. Eckert,Manuela Zaccolo,Tullio Pozzan,Robert D. Harvey +6 more
TL;DR: An adenovirus-based approach was developed to express this recombinant protein complex in adult cardiac myocytes and use it to monitor changes in cAMP activity produced by beta-adrenergic and muscarinic receptor activation.
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