Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
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Dissertation
Effects of Erythroxylum Cuneatum (Miq.) Kurz on cellular and synaptic adaptation of chronic morphine-addicted human neuroblastoma cell line at protein level
TL;DR: The administration of ECAl at the optimal doses was postulated to minimise the withdrawal, dependence, and tolerance against morphine-addicted cell and showed that ECAl possesses anti-withdrawal properties.
Dissertation
Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets
TL;DR: The experimental data suggest that the localization of PKA I to lipid rafts is mediated by interaction with A-kinase anchoring proteins (AKAPs), and PKA signaling events were reversed when potential PKA type I interactions with AKAPs were disrupted with competitive peptides.
Posted ContentDOI
Gsα stimulation of mammalian adenylate cyclases regulated by their hexahelical membrane anchors
TL;DR: It is reported that Gsα stimulation of human AC isoforms 2, 3, 5, and 9 expressed in Sf9 cells is inhibited by serum as is AC activity in membranes from rat brain cortex, which establishes a linkage in ACs, in which the membrane anchors, as receptors, transduce extracellular signals to the cytosolic catalytic dimer.
Positive Trafficking Pathways of a Voltage Gated Potassium Channel
TL;DR: Channel trafficking is demonstrated as a mechanism for the positive regulation of the Kv1.2 ionic current and a novel role is identified for PRMT8, as a regulator of biosynthetic protein trafficking.
Journal ArticleDOI
Role of cyclic nucleotide phosphodiesterases in the cAMP compartmentation in cardiac cells
Delphine Mika,Jérôme Leroy,Jérôme Leroy,Grégoire Vandecasteele,Grégoire Vandecasteele,Rodolphe Fischmeister,Rodolphe Fischmeister +6 more
TL;DR: The main findings that support the cAMP compartmentation hypothesis in cardiac cells are summarized and the potential benefits that could be awaited from the manipulation of specific PDE subtypes in heart failure are presented.
References
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Journal ArticleDOI
Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
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Store-operated calcium channels.
Anant B. Parekh,James W. Putney +1 more
TL;DR: The key electrophysiological features of I(CRAC) and other store-operated Ca(2+) currents and how they are regulated are described, and recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca( 2+) entry pathway are considered.
Journal ArticleDOI
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
TL;DR: This article reviews many of the more important aspects about the structure, cellular localization, and regulation of each family of phosphodiesterases and places particular emphasis on new information obtained in the last few years about how differential expression andregulation of individual phosphodiesters relate to their function(s) in the body.
Journal ArticleDOI
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
TL;DR: Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with G TP, and this theory may apply generally to membrane signal transduction involving surface receptors.
Journal ArticleDOI
Lipid Rafts: Elusive or Illusive?
TL;DR: There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids, and it seems that a definitive proof of raft existence has yet to be obtained.
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