Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Cyclic AMP oscillations in insulin-secreting cells
TL;DR: It is concluded that cell metabolism directly controls cAMP, and that glucose-induced cAMP oscillations regulate the magnitude and kinetics of insulin exocytosis.
Journal ArticleDOI
Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype
Tiffany S. Dwyer,Joseph B. O’Brien,Christopher Ptak,Justin LaVigne,Daniel P. Flaherty,Val J. Watts,David L. Roman +6 more
TL;DR: A novel, potent, dithiophene scaffold is discovered for inhibition of the AC1- and AC8-CaM PPI, the most potent fully efficacious inhibitor of AC8 activity known to-date.
Journal ArticleDOI
Localised intracellular signalling in neurons.
Nikita Gamper,Nikita Gamper +1 more
TL;DR: Current developments in the understanding of localised neuronal signalling cascades were discussed at the symposium entitled ‘Localised intracellular signalling in neurons’ held on 1 July 2014 during the Physiological Society’s annual meeting, Physiology 2014, in London.
Posted Content
Transcriptional Response of SK-N-AS Cells to Methamidophos
Akos Vertes,Albert-Baskar Arul,Peter Avar,Andrew R. Korte,Lida Parvin,Ziad J. Sahab,Deborah I. Bunin,Merrill Knapp,Denise Nishita,Andrew Poggio,Mark-Oliver Stehr,Carolyn L. Talcott,Brian Michael Davis,Christine A. Morton,Christopher J. Sevinsky,Maria I. Zavodszky +15 more
TL;DR: Several processes that appeared to be upregulated in cells treated with methamidophos including: unfolded protein response, response to cAMP, calcium ion response, and cell-cell signaling are identified.
References
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Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
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Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
TL;DR: This article reviews many of the more important aspects about the structure, cellular localization, and regulation of each family of phosphodiesterases and places particular emphasis on new information obtained in the last few years about how differential expression andregulation of individual phosphodiesters relate to their function(s) in the body.
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The role of hormone receptors and GTP-regulatory proteins in membrane transduction
TL;DR: Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with G TP, and this theory may apply generally to membrane signal transduction involving surface receptors.
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Lipid Rafts: Elusive or Illusive?
TL;DR: There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids, and it seems that a definitive proof of raft existence has yet to be obtained.
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