Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
More filters
Journal ArticleDOI
Principles of c-di-GMP signalling in bacteria.
TL;DR: This Review focuses on emerging principles of c-di-GMP signalling using selected systems in different bacteria as examples.
Journal ArticleDOI
A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
TL;DR: Evidence is examined that forms the basis of this coupled-clock system concept in cardiac SANCs, where G protein-coupled receptors signaling creates pacemaker flexibility, ie, effects changes in the rhythmic action potential firing rate, by impacting on these very same factors that regulate robust basal coupled- clock system function.
Journal ArticleDOI
Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
TL;DR: The role of Caveolae/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target are reviewed.
Journal ArticleDOI
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
TL;DR: Genes for these important regulatory enzymes are linked to schizophrenia, stroke and asthma, thus indicating the therapeutic potential that selective inhibitors could have as anti-inflammatory, anti-depressant and cognitive enhancer agents.
Journal ArticleDOI
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
More filters
Journal ArticleDOI
Intracellular targeting of the photoprotein aequorin: a new approach for measuring, in living cells, Ca2+ concentrations in defined cellular compartments.
TL;DR: Data indicate that mitochondria “sense” very accurately the cytosolic Ca2+ concentration ([Ca2+]i), and after cell stimulation [Ca2-]m rises to values capable of activating the Ca2-sensitive mitochondrial dehydrogenases.
Journal ArticleDOI
Calcium-dependent adenylate cyclase of pituitary tumor cells.
TL;DR: Ca2+ was observed to reduce the extent of enzyme destabilization which occurred during pretreatments at warm temperatures, and both the inhibitory and stimulatory responses to Ca2+ were shifted by calmodulin to lower respective concentrations of the cation.
Journal ArticleDOI
Hippocampal Neurons Express a Calcineurin-Activated Adenylyl Cyclase
TL;DR: Analysis of cultured neurons from calcineurin-/- mice confirmed that hippocampal neurons exhibit a calcineURin-dependent cAMP increase, which may contribute to some forms of neuroplasticity.
Journal Article
Recent advances in the study of Ca2+/CaM-activated phosphodiesterases: expression and physiological functions.
Journal ArticleDOI
Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle.
Alexander Ivanov,Volodymyr Gerzanich,Svetlana Ivanova,Ryan DenHaese,Orest Tsymbalyuk,J. Marc Simard +5 more
TL;DR: The data are consistent with the hypothesis that hyperpolarization is critical for a proliferative response and are the first to implicate AC‐5 and maxi‐KCa channels in gene activation related to EGFR signalling in native contractile VSMC.
Related Papers (5)
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Manuela Zaccolo,Tullio Pozzan +1 more
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
Marco Conti,Joseph A. Beavo +1 more