Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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β-Adrenergic Activation of Electrogenic K+ and Cl- Secretion in Guinea Pig Distal Colonic Epithelium Proceeds via Separate cAMP Signaling Pathways
TL;DR: Beta-adrenergic activation of electrogenic Cl(-) and K(+) secretion, respectively, required tmAC- and sAC-dependent signaling pathways and responses to specific activators and inhibitors suggested that protein kinase A was not involved in activating peak or sustained components of (epi)I(sc), but the cAMP-dependent guanine nucleotide exchange factor, Epac, may contribute.
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Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu
Laura Jo Ayling,Stephen J. Briddon,Michelle L. Halls,Gerald R.V. Hammond,Luis Vaca,Jonathan Pacheco,Stephen J. Hill,Dermot M.F. Cooper +7 more
TL;DR: An adenylyl cyclase is shown not just to act as a scaffold, but also to actively orchestrate its own micro-environment, by associating with the cytoskeleton and controlling the association by producing cAMP, to yield a highly organized signalling hub.
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Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.
Carlo Spirli,Valeria Mariotti,Valeria Mariotti,Ambra Villani,Luca Fabris,Romina Fiorotto,Mario Strazzabosco,Mario Strazzabosco +7 more
TL;DR: It is demonstrated that inhibiting cell proliferation, which is induced by increased levels of cAMP, may represent a novel therapeutic target to slow the progression of the disease.
Journal ArticleDOI
Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot.
TL;DR: A wide overview of studies regarding the involvement of cyclic nucleotides, as well as their upstream and downstream molecules, in physiological and pathological mnemonic processes and the importance of emerging imaging tools like Förster resonance energy transfer imaging and optogenetics in detecting, measuring and manipulating the action ofcyclic nucleotide signaling cascades is provided.
Journal ArticleDOI
Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier
TL;DR: Findings identify nonneuronal tau as a critical cAMP-responsive microtubules-associated protein that controls microtubule architecture and endothelial cell barrier function.
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