Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Principles of c-di-GMP signalling in bacteria.
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
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AKAP signaling complexes: getting to the heart of the matter.
TL;DR: A review will explore recent development that illustrates the role of multiprotein complexes in the regulation of cAMP signaling.
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Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.
Yasmin Shakur,Lena Stenson Holst,Tova Rahn Landström,Matthew A. Movsesian,Eva Degerman,Vincent C. Manganiello +5 more
TL;DR: This chapter discusses some general information about cyclic nucleotide phosphodiesterases (PDEs), and discusses the PDE3 gene family, emphasizing the molecular biology, structure/function relationships, and cellular regulation and functional roles of Pde3s, as well as physiological/pharmacological actions, therapeutic applications, and potential benefits of PDE2 inhibitors.
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Endogenous TRPC1, TRPC3, and TRPC7 Proteins Combine to Form Native Store-operated Channels in HEK-293 Cells
TL;DR: Endogenously expressed canonical transient receptor potential (TRPC) homologs participate in forming heteromeric store-operated channels, whereas TRPC1, TRPC3, and TRPC7 can also participate in form heteromersic receptor- operated channels.
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Functional stoichiometry and local enrichment of calmodulin interacting with Ca2+ channels
TL;DR: This estimate indicates marked enrichment of local CaM, as if a “school” of nearby CaMs were poised to enhance the transduction of localCa2+ entry into diverse signaling pathways.
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