Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
More filters
Journal ArticleDOI
Principles of c-di-GMP signalling in bacteria.
TL;DR: This Review focuses on emerging principles of c-di-GMP signalling using selected systems in different bacteria as examples.
Journal ArticleDOI
A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
TL;DR: Evidence is examined that forms the basis of this coupled-clock system concept in cardiac SANCs, where G protein-coupled receptors signaling creates pacemaker flexibility, ie, effects changes in the rhythmic action potential firing rate, by impacting on these very same factors that regulate robust basal coupled- clock system function.
Journal ArticleDOI
Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
TL;DR: The role of Caveolae/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target are reviewed.
Journal ArticleDOI
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
TL;DR: Genes for these important regulatory enzymes are linked to schizophrenia, stroke and asthma, thus indicating the therapeutic potential that selective inhibitors could have as anti-inflammatory, anti-depressant and cognitive enhancer agents.
Journal ArticleDOI
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
More filters
Journal ArticleDOI
Space matters: local and global dendritic Ca2+ compartmentalization in cortical interneurons.
Jesse H. Goldberg,Rafael Yuste +1 more
TL;DR: Dendrites of pyramidal neurons are complex, electrically active structures that can produce local and global Ca(2+) compartments and probably also implement subclass-specific plasticity and homeostasis.
Journal ArticleDOI
Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants.
TL;DR: The deduced amino-acid sequence of the longest form of rat PDE11A splice variant, RNPDE11A4, was 94% identical with that of the human variant (HSPDE11 a4), which indicates unique characteristics of PDE 11A splicing variants.
Journal ArticleDOI
Control of Developmental Transitions in the Cyclic AMP Signalling System of Dictyostelium discoideum
Albert Goldbeter,Lee A. Segel +1 more
TL;DR: A theoretical model is presented which demonstrates that the proximal cause of the transitions between different types of behavior may be slow changes in the activities of the enzymes adenylate cyclase and phosphodiesterase, and compares with the time course observed for the synthesis of these enzymes after starvation.
Journal ArticleDOI
Novel, isotype-specific sensors for protein kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET).
TL;DR: It is demonstrated that PKA type II holoenzyme was rendered insensitive to beta-adrenergic receptor stimulation with isoproterenol when anchoring to the plasma membrane of COS-7 cells was disrupted by either using Ht31 peptide or by depletion of membrane cholesterol.
Journal ArticleDOI
Regulation of adenylyl cyclase by membrane potential
TL;DR: The results indicate no direct sensitivity of cerebellar granule cell adenylyl cyclase to membrane potential, but it is demonstrated that, as a result of membrane depolarization, the influx of Na+, as well as Ca2+, will elevate cAMP levels.
Related Papers (5)
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Manuela Zaccolo,Tullio Pozzan +1 more
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
Marco Conti,Joseph A. Beavo +1 more