Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Principles of c-di-GMP signalling in bacteria.
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A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
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Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
TL;DR: The role of Caveolae/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target are reviewed.
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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
TL;DR: Genes for these important regulatory enzymes are linked to schizophrenia, stroke and asthma, thus indicating the therapeutic potential that selective inhibitors could have as anti-inflammatory, anti-depressant and cognitive enhancer agents.
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
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Role of Caveolae and Caveolins in Health and Disease
TL;DR: The mechanisms by which caveolae and caveolins participate in human disease processes are provided, including diabetes, cancer, cardiovascular disease, atherosclerosis, pulmonary fibrosis, and a variety of degenerative muscular dystrophies.
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Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors
TL;DR: This work uses quantitative high-resolution MS to specifically detect proteins depleted from rafts by cholesterol-disrupting drugs, resulting in a set of 241 authentic lipid raft components, providing the first large-scale and unbiased evidence for the connection of rafts with signaling and place limits on the fraction of plasma membrane composed by rafts.
Journal ArticleDOI
Golf: an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction
David T. Jones,Randall R. Reed +1 more
TL;DR: Evidence is presented suggesting that this G protein, termed Golf, mediates olfaction, and the expression of Golf alpha in S49 cyc- kin- cells, a line deficient in endogenous stimulatory G proteins, demonstrates its capacity to stimulate adenylate cyclase in a heterologous system.
Journal ArticleDOI
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Yanqiu Chen,Martin J. Cann,Tatiana N. Litvin,Vadim Iourgenko,Meeghan L. Sinclair,Lonny R. Levin,Jochen Buck +6 more
TL;DR: It is demonstrated here that bicarbonate directly stimulates mammalian soluble adenylyl cyclase (sAC) activity in vivo and in vitro in a pH-independent manner, which suggests that bICarbonate regulation of cAMP signaling plays a fundamental role in many biological systems.
Journal ArticleDOI
Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.
TL;DR: Six new phosphodiesterase genes have been discovered and characterized, and new strategies have been employed to determine PDE function in model systems including the use of antisense oligonucleotide and disruption techniques.
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