Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
More filters
Journal ArticleDOI
Principles of c-di-GMP signalling in bacteria.
TL;DR: This Review focuses on emerging principles of c-di-GMP signalling using selected systems in different bacteria as examples.
Journal ArticleDOI
A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
TL;DR: Evidence is examined that forms the basis of this coupled-clock system concept in cardiac SANCs, where G protein-coupled receptors signaling creates pacemaker flexibility, ie, effects changes in the rhythmic action potential firing rate, by impacting on these very same factors that regulate robust basal coupled- clock system function.
Journal ArticleDOI
Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
TL;DR: The role of Caveolae/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target are reviewed.
Journal ArticleDOI
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
TL;DR: Genes for these important regulatory enzymes are linked to schizophrenia, stroke and asthma, thus indicating the therapeutic potential that selective inhibitors could have as anti-inflammatory, anti-depressant and cognitive enhancer agents.
Journal ArticleDOI
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
More filters
Journal ArticleDOI
Inhibition of Adenylyl Cyclase by Caveolin Peptides
TL;DR: Kinetic studies showed that the caveolin-1 peptide decreased the maximal rate value of type V without changing the Michaelis constant value for the substrate ATP, suggesting that caveolin may be another cellular component that regulates adenylyl cyclase catalytic activity.
Journal ArticleDOI
Recent developments in non-excitable cell calcium entry.
TL;DR: Recent developments in the field are summarized, and discussion has largely focussed on whether homologue(s) of the Drosophila TRP ('Transient Receptor Potential') protein is/are the elusive channel, or at least a part of it.
Journal ArticleDOI
Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels
TL;DR: Recent advances in understanding the subunit composition and the mechanisms and roles for Ca2+/CaM-dependent inhibition in olfactory and rod CNG channels are reviewed.
Journal ArticleDOI
Dependence of the Ca2+-inhibitable Adenylyl Cyclase of C6–2B Glioma Cells on Capacitative Ca2+ Entry
TL;DR: Results not only establish an intimate spatial relationship between an endogenously expressed Ca2+-inhibitable adenylyl cyclase with capacitativeCa2+ entry sites but also provide a physiological role for capacitative Ca2- entry other than store refilling.
Journal ArticleDOI
Physiological mechanisms of TRPC activation.
TL;DR: The possibility that these diverse experimental findings arise because TRPC channels can, under both experimental as well as physiological conditions, be activated in three distinct ways, possibly depending on their subunit composition and/or signaling complex environment is discussed.
Related Papers (5)
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Manuela Zaccolo,Tullio Pozzan +1 more
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
Marco Conti,Joseph A. Beavo +1 more