Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Principles of c-di-GMP signalling in bacteria.
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
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TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
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Journal ArticleDOI
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains
Jonathan H. Zippin,Yanqiu Chen,Patrick C. Nahirney,Patrick C. Nahirney,Margarita Kamenetsky,Mark S. Wuttke,Donald A. Fischman,Lonny R. Levin,Jochen Buck +8 more
TL;DR: It is demonstrated that sAC is distributed in specific subcellular compartments: mitochondria, centrioles, mitotic spindles, mid‐bodies, and nuclei, all of which contain cAMP targets, suggesting a model in which local concentrations of cAMP are regulated by individual adenylyl cyclases targeted to specific microdomains throughout the cell.
Journal ArticleDOI
Dynamics in the plasma membrane: how to combine fluidity and order
Didier Marguet,Didier Marguet,Pierre-François Lenne,Pierre-François Lenne,Hervé Rigneault,Hervé Rigneault,Hai-Tao He,Hai-Tao He +7 more
TL;DR: The basic concepts of Brownian diffusion and lipid domain formation in model membranes are summarized and the development of ideas and tools in this field are tracked, outlining key results obtained on the dynamic processes at work in membrane structure and assembly.
Journal ArticleDOI
Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes
TL;DR: Using a detergent-free method for isolation of sarcolemmal caveolae from primary cultures of adult rat ventricular myocytes, it is demonstrated that the muscarinic cholinergic agonist carbachol promotes the translocation of mAchR into low density gradient fractions containing most myocyte caveolin-3 and eNOS.
Journal ArticleDOI
Chromatin remodeling enzymes: who's on first?
TL;DR: Recent developments concerning the role of chromatin remodeling enzymes in gene regulation are reviewed, and several models to explain how different chromatin renovation activities can be functionally coupled are proposed.
Journal ArticleDOI
Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters.
Michael D. Allen,Jin Zhang +1 more
TL;DR: A new FRET-based A-kinase activity reporter (AKAR), AKAR3, is developed with a dynamic range of 31-41%, twice that of predecessors, indicating differential regulation of PKA activity at different subcellular locations.
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