Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
Caroline Bull Melsom,Marie-Victoire Cosson,Øivind Ørstavik,Ngai Chin Lai,Ngai Chin Lai,H. Kirk Hammond,H. Kirk Hammond,Jan-Bjørn Osnes,Tor Skomedal,Viacheslav O. Nikolaev,Finn Olav Levy,Kurt A. Krobert +11 more
TL;DR: The data suggest that AC6 is tightly regulated by intrinsic receptor-independent Gi activity, thus providing a mechanism for maintaining low basal cAMP levels in the functional compartment that regulates contractility.
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Regulation of α‐cell glucagon secretion: The role of second messengers
TL;DR: In this article , the impact of second messengers on α-cell electrical activity, intracellular Ca2+ dynamics and cell exocytosis was discussed, and the possibility that the interaction between different secondmessengers may play a key role in the glucose-regulation of glucagon secretion was highlighted.
Journal ArticleDOI
Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells
TL;DR: The results showed that AC7 affected intracellular cAMP level and influenced ATRA-induced differentiation of APL cells, and revealed that miR-192 could directly target AC7 expression and knockdown of mi R-192 promoted ATra-induced APL cell differentiation by regulating AC7expression.
Journal ArticleDOI
High-performance optical control of GPCR signaling by bistable animal opsins MosOpn3 and LamPP in a molecular property–dependent manner
Mitsumasa Koyanagi,Baoguo Shen,Takashi Nagata,Lanfang Sun,Seiji Wada,Satomi Kamimura,Eriko Kage-Nakadai,Akihisa Terakita +7 more
TL;DR: In this article , two animal opsins, MosOpn3 and LamPP, are used in optogenetics equivalently to ChR2 in terms of retinal requirement.
Journal ArticleDOI
Distribution of adenylyl cyclases in the rat ovary by immunofluorescence microscopy.
P. Bagavandoss,S. Grimshaw +1 more
TL;DR: The study reveals the redundancy of adenylyl cyclases present in the rat ovary and, therefore, implies potential regulation of follicular and corpus luteum physiology by cyclic adenosine 3′,5′‐monophosphate generated through distinct adenyll cyclases.
References
More filters
Journal ArticleDOI
Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
Journal ArticleDOI
Store-operated calcium channels.
Anant B. Parekh,James W. Putney +1 more
TL;DR: The key electrophysiological features of I(CRAC) and other store-operated Ca(2+) currents and how they are regulated are described, and recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca( 2+) entry pathway are considered.
Journal ArticleDOI
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
TL;DR: This article reviews many of the more important aspects about the structure, cellular localization, and regulation of each family of phosphodiesterases and places particular emphasis on new information obtained in the last few years about how differential expression andregulation of individual phosphodiesters relate to their function(s) in the body.
Journal ArticleDOI
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
TL;DR: Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with G TP, and this theory may apply generally to membrane signal transduction involving surface receptors.
Journal ArticleDOI
Lipid Rafts: Elusive or Illusive?
TL;DR: There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids, and it seems that a definitive proof of raft existence has yet to be obtained.
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