Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Principles of c-di-GMP signalling in bacteria.
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Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Rachna Sadana,Carmen W. Dessauer +1 more
TL;DR: The latest on AC knockout and overexpression studies are explored to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.
References
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Ca2+ Selectivity and Fatty Acid Specificity of the Noncapacitative, Arachidonate-regulated Ca2+ (ARC) Channels
TL;DR: Examination of the ability of various fatty acids to activate the ARC channels demonstrated that activation does not reflect any nonspecific membrane fluidity or detergent effects, shows a high degree of specificity for arachidonic acid over other fatty acids (especially monounsaturated and saturated fatty acids), and is independent of any arachidsonic acid metabolite.
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Purification and characterization of a soluble form of mammalian adenylyl cyclase
TL;DR: An engineered, soluble form of mammalian adenylyl cyclase has been expressed in Escherichia coli and purified by three chromatographic steps, and is activated synergistically by Gsα and forskolin and inhibited directly by the G protein βγ subunit complex.
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Oscillation of Cyclic Adenosine Monophosphate Concentration during the Myocardial Contraction Cycle
TL;DR: In this paper, the authors found that cyclic AMP can be used as a beat-to-beat regulator of myocardial contractility, and that peak concentrations of cyclic amp follow peak development of systolic tension.
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Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase.
TL;DR: Findings provide the first direct evidence that calcium inhibition of AC6 is essential for endothelial gap formation, which virtually abolished thrombin-induced gap formation in PMVECs.
Journal ArticleDOI
Residence of Adenylyl Cyclase Type 8 in Caveolae Is Necessary but Not Sufficient for Regulation by Capacitative Ca2+Entry
TL;DR: It is concluded that not all adenylyl cyclases reside in caveolae, the calmodulin-binding domain in the N terminus of AC8 does not play a role in caveolar targeting, and theN terminus does play a roles in associating AC8 with factors that confer sensitivity to CCE, which is essential but not sufficient for regulation by CCE.
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