Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
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cAMP/Protein Kinase A Activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP Release from Rat Skeletal Muscle during Low pH or Contractions
TL;DR: The data suggest that CFTR-regulated release contributes to ATP release from contracting muscle in vivo, and that cAMP and PKA are involved in the activation of CFTR during muscle contractions or acidosis; NHE and NCX may be involved inThe signal transduction pathway.
Journal ArticleDOI
Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.
TL;DR: Co-immunoprecipitation and subcellular-fractionation experiments have shown that DmPDE5/6 interacts with DmPrBP/delta in Drosophila S2 cells, suggesting that, in addition to prenylation and interaction with D mPrBP /delta, further functional membrane-targeting signals exist within Dm PDE 5/6.
Journal ArticleDOI
Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca(2+) stores and inhibition of capacitative calcium entry.
TL;DR: This study provides the first evidence that inhibition of PDE4 or p38-MAPK potentiates the vasodilator effect of cAMP-elevating agents in rat aortic myocytes.
BookDOI
Store-operated Ca2+ entry (SOCE) pathways
TL;DR: Store-operated Ca2+ entry (SOCE) pathways - Libros de Medicina - Cardiologia general - 155,95
through the Spatial Signature Drives Gene Expression
TL;DR: Spatialsignature within a global Ca oscillation, rather than the oscil-lation itself, that triggers c-fos gene expression, greatly increases the versatility of Ca as a second messenger, enhances the efficacy of Ca.
References
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