Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
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References
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Regulatory properties of adenylate cyclases type 5 and 6: A progress report.
Michael A. Beazely,Val J. Watts +1 more
TL;DR: The discovery of novel regulatory mechanisms for AC5 and AC6 and their potential role in crucial physiological processes provide new avenues for research into therapeutic interventions targeting the cyclic AMP pathway.
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Review article: cyclic AMP sensors in living cells: what signals can they actually measure?
Thomas C. Rich,Jeffrey W. Karpen +1 more
TL;DR: Two recently developed methods for detecting cAMP levels in living cells are described, which have given us the first glimpses of cAMP signals within living cells.
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Splice Variants of Type VIII Adenylyl Cyclase DIFFERENCES IN GLYCOSYLATION AND REGULATION BY Ca2+/CALMODULIN
TL;DR: Three alternatively spliced type VIII adenylyl cyclase messages have been identified by cDNA cloning and amplification from rat brain cDNA, and the differences in the structural and enzymatic properties are discussed.
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Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins.
Jost H. Weber,Andrey E. Vishnyakov,Kristina Hambach,Anita Schultz,Joachim E. Schultz,Jürgen U. Linder +5 more
TL;DR: A putative N-terminal ion channel domain contains a canonical S4 voltage-sensor and a canonical potassium pore-loop located C-terminally after the last transmembrane span on the cytoplasmic side of the adenylyl cyclase.
Journal ArticleDOI
Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing hormone secretion in GT1 cells.
Elizabeth A. Vitalis,James L. Costantin,Pei-San Tsai,Hideya Sakakibara,Sreenivasan Paruthiyil,Taroh Iiri,Jean-François Martini,Michiyoshi Taga,Amy L. H. Choi,Andrew Charles,Richard I. Weiner +10 more
TL;DR: The stimulation of GnRH release by elevations in cAMP appears to be the result of depolarization of the neurons initiated by increased cation conductance by cAMP-gated cation channels.
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