Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TLDR
The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.Abstract:
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations, this regulation can be re...read more
Citations
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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
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References
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Journal ArticleDOI
A Critical Interplay between Ca2+ Inhibition and Activation by Mg2+ of AC5 Revealed by Mutants and Chimeric Constructs
TL;DR: Both low and high affinity inhibition by Ca2+ are exerted on different conformations of the Mg2+-binding sites in the catalytic domain of AC5, indicating a simple mutation in a shared domain.
Journal ArticleDOI
Augmentation of cardiac contractility with no change in L-type Ca2+ current in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8)
Marie Georget,Philippe Mateo,Grégoire Vandecasteele,Jonas Jurevičius,Larissa Lipskaia,Nicole Defer,Jacques Hanoune,J. A. Hoerter,Rodolphe Fischmeister +8 more
TL;DR: Cardiac expression of AC8 leads to an increase in cAMP that activates specifically Ca2+ uptake into the sarcoplasmic reticulum but notCa2+ influx at the sarcolemma, suggesting a strong compartmentation of the cAMP signal.
Journal ArticleDOI
Adenylyl cyclase type-VIII activity is regulated by Gβγ subunits
TL;DR: It is demonstrated in intact mammalian cell system that AC-VIII is inhibited by μ-opioid receptor activation and that this inhibition is pertussis toxin sensitive, and that Gβγ subunits inhibit AC-vIII activity, while constitutively active αi/o subunits do not.
Journal ArticleDOI
Expression of type V adenylyl cyclase is required for epidermal growth factor-mediated stimulation of cAMP accumulation.
TL;DR: The expression of AC V isoform confers specificity to the ability of EGF to stimulate AC activity, and stimulation of AC activity in AC V transfectants involved the participation of Gsα, a finding consistent with previous data concerning EGF effects on cardiac AC.
Journal ArticleDOI
Ca2+, Sr2+, and Ba2+ Identify Distinct Regulatory Sites on Adenylyl Cyclase (AC) Types VI and VIII and Consolidate the Apposition of Capacitative Cation Entry Channels and Ca2+-sensitive ACs
Chen Gu,Dermot M.F. Cooper +1 more
TL;DR: Whereas Sr2+ was rather ineffective at regulating these cyclases (particularly ACVI) in vitro, adequate concentrations accumulated in the vicinity of these enzymes as a consequence of capacitative cation entry to partially regulate both of these activities in vivo.
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