Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Effect of Dietary Vitamin E on Growth Performance, Immunity and Antioxidant Capacity in Male Jiangnan White Goslings from 1 to 28 d of Age
TL;DR: In this article , the effects of different dietary levels of vitamin E (VE) on the growth performance, immunity and antioxidant capacity of goslings were investigated, and the results showed that dietary VE supplementation could significantly reduce the feed/gain ratio (F/G) (p < 0.05).
Dissertation
Étude comparative de la réactivité des cellules du système immunitaire (invertébrés et vertébrés) vis-à-vis des pesticides
TL;DR: Le groupe des insecticides les plus couramment utilises sont les neonicotinoides et leurs residus ont par exemple ete trouves dans les fruits and legumes traites, le pollen and le miel, ainsi that dans l’organisme des abeilles.
Journal ArticleDOI
Antioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects
TL;DR: In vivo, MitoQ alleviated pancreatic fibrosis and inhibited OS in the cerulein-induced murine CP model and in vitro, it inhibited PSC activation as well as the subsequent development of the profibrogenic phenotypes by balancing out the levels of free radicals and the intracellular antioxidant system.
Journal ArticleDOI
The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC. on antioxidant activity and protective ability against cell injury.
Qingying Zhang,Tianzhi Yang,Dong Peng Li,Mengyu Ma,X. L. Liang,Zixing Ma,Qianglong Ye,Han-Bing Yang,Minghui Li,Ailan Qu,Yao Chen +10 more
TL;DR: DG-SDH formulated at a ratio of 3:2 has the best synergistic effects in antioxidant activity and promote the neuroprotection against hydrogen peroxide and will be an excellent candidate to be developed as a functional food ingredients or nutraceuticals for neurodegenerative diseases.
Journal ArticleDOI
Evaluation of mutagenesis, necrosis and apoptosis induced by omeprazole in stomach cells of patients with gastritis
Ana Maria Oliveira Ferreira da Mata,Márcia Fernanda Correia Jardim Paz,Ag-Anne Pereira Melo de Menezes,Antonielly Campinho dos Reis,Bruna da Silva Souza,Carlos Dimas de Carvalho Sousa,Sônia Alves Machado,Thiago Soares Gondim Medeiros,Chandan Kumar Sarkar,Muhammad Torequl Islam,Javad Sharifi-Rad,Sevgi Durna Daştan,Mohammed M. Alshehri,João Marcelo de Castro e Sousa,Ana Amélia de Carvalho Melo Cavalcante +14 more
TL;DR: In this paper , the authors evaluated the cytogenetic effects of omeprazole in stomach epithelial cells of patients with gastritis in presence and absence of Helicobacter pylori infection.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.