Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Melatonin modulates endometrial decidualization via NOTCH1-NRF2-FOXO1-GSH pathway.
TL;DR: In this article , the authors found that melatonin did not alter the proliferation of human endometrial stromal cells (ESCs) as well as cell cycle progress, but suppressed the ESC differentiation after binding to the MTNR1B receptor which was visualized in decidualizing ESCs.
Journal ArticleDOI
The role of nutritional-immunological indices in estimating serum LPS and antioxidant enzyme activity and sepsis status in female dogs with pyometra caused by E. coli.
Murat Onur Yazlik,İpek Mutluer,U. Kaya,Hüseyin Özkan,İnci Başak Müştak,Hatice Esra Çolakoğlu,Mehmet Rıfat Vural +6 more
TL;DR: In this article , a cost-effective nutritional-immunological indices (hemoglobin, albumin, lymphocyte, platelet score; prognostic nutritional index (PNI); albumin hemoglobin index (AHI)), serum LPS and antioxidant activity were used to diagnose pyometra and related sepsis status in dogs.
Mosul journal of nursing
TL;DR: It is demonstrated that hyperthyroid patients have increased level of malondialdehyde and decreased levels of total antioxidants capacity than the control group while hyperthy thyroid patients treated with Carbimazole for two months have decreased level of MDA and increased levels of T-AOC than their levels before treatment.
Journal ArticleDOI
Alterations in the omics profiles in mevalonate pathway-inhibited cancer cells.
Tomoko Warita,Nanami Irie,Yaxuan Zhou,J. Tashiro,A. Sugiura,Zoltán N. Oltvai,Katsuhiko Warita +6 more
TL;DR: In this article , the effects of statins on cancer cells in vitro were investigated and it was shown that combining statins with inhibitors of polyamine metabolism (cell proliferation and protein translation), purine metabolism (DNA synthesis), glycolytic system (energy production), and pentose phosphate pathway (antioxidant stress) might enhance the anticancer effects.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.