Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Synergistic effect of folic acid and galantamine against experimentally induced oxidative stress in IMR 32 cells
TL;DR: Findings of these dose reliant toxicity study of Galantamine, Folic acid and their combination suggest that these has higher potency when given together and shows synergistic effect.
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A ratiometric fluorescence-based colorimetric sensor for the portable analysis of antioxidants via smartphone
TL;DR: In this article , a ratiometric fluorescence-based colorimetric sensor was developed for the portable analysis of antioxidant capacity (AOC) using a smartphone, which used carbon dots (CDs) and o-phenylenediamine (OPD) as fluorescence signal substrate and manganese dioxide nanosheets (MnO2 NSs) as a fluorescence quencher, a catalyst of the substrate.
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Sub-Acute Toxicity Assessment of a Polyherbal Product “Combo” on Liver and Kidney Function Indices in Experimental Rats
Efecto antioxidante del extracto de Moringa oleifera en la maduración in vitro de oocitos bovinos
Amaya Barragán,Lina Marcela +1 more
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Forsythin inhibits β-hydroxybutyrate-induced oxidative stress in bovine macrophages by regulating p38/ERK, PI3K/Akt, and Nrf2/HO-1 signaling pathways
TL;DR: In this paper , the effects of FOR on β-HB-stimulated bovine macrophages (BMs) have been investigated, and it was shown that FOR significantly reduced the mRNA levels of IL-1β and IL-6.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.