Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Journal ArticleDOI
Supersensitive CeOx-based nanocomposite sensor for the electrochemical detection of hydroxyl free radicals
Surachet Duanghathaipornsuk,Dong-Shik Kim,Tamara L. Phares,Cheng-Han Li,Joerg R. Jinschek,Ana C. Alba-Rubio +5 more
TL;DR: A supersensitive nanosensor integrated with an electrochemical method to measure the concentration of hydroxyl radicals (˙OH) in vitro was presented in this paper. But, the performance of the sensor was limited to 0.6 μM.
Journal ArticleDOI
The possible alleviating effect of saffron on chlorpyrifos experimentally induced cardiotoxicity: Histological, immunohistochemical and biochemical study.
TL;DR: The study concludes that crocin can alleviate the toxic effect of chlorpyrifos caused by oxidative stress on cardiac muscle and evaluates the possible protective role of crocin using biochemical and histological methods.
Dissertation
Synthesis, detection and quantification of inulooligosaccharides and fructooligosaccharides by extracellular and intracellular inulinase and fructosyltransferase enzymes isolated from coprophilous fungi.
TL;DR: This book aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
Journal ArticleDOI
Epigallocatechin-3-gallate protects immunity and liver drug-metabolism function in mice loaded with restraint stress.
Huaqiao Tang,Suqi Hao,Xingying Chen,Yinglun Li,Zhongqiong Yin,Yuanfeng Zou,Xu Song,Lixia Li,Gang Ye,Ling Zhao,Hongrui Guo,Ran He,Cheng Lv,Juchun Lin,Fei Shi +14 more
TL;DR: The data suggest that EGCG possesse hepatic- and immune-protective properties against restraint stress through its anti-oxidant, anti-inflammatory and immunomodulatory activities.
Dissertation
Redox biology in retinal degeneration
Ruiz López,M Ana +1 more
TL;DR: The retina in health and disease, and progesterone and Norgestrel: mechanism of action, and the role of antioxidants as therapeutic molecules in this work.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.