Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Neuroprotective effects of Flaveria bidentis and Lippia salsa extracts on SH-SY5Y cells
TL;DR: Investigating the cytotoxicity, cellular protection against K+-depolarization and antioxidant activity in SH-SY5Y neuroblastoma cells for these extracts and compound 3 demonstrated that beyond acting as acetylcholinesterase inhibitors, they exhibited neuroprotective effects against KCl-induced-Ca2 + overload and oxidative stress.
Journal ArticleDOI
Application of Cu 2+ -based electron spin resonance spectroscopy in measurement of antioxidant capacity of fruits
TL;DR: Based on Pearson’s correlation test, the results obtained by CUPRAC and DPPH methods were both significantly correlated with these obtained by the present method, which indicated that the novel method was reliable.
Journal ArticleDOI
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Yinzhong Lu,Wenyi Zhang,Bing Zhang,Stefan H. Heinemann,Toshinori Hoshi,Shangwei Hou,Guangming Zhang +6 more
TL;DR: In this article, the authors explored the potential role of BOXes and the involved mechanisms in neuronal function and demonstrated that primary cortical neurons and neuroblastoma cells undergo an adaptive response against BOX A- and BOX B-mediated oxidative stress by activation of multiple antioxidant responses, in part through the Nrf2 pathway, which provides in-depth insights into the pathophysiological mechanism of DIND after SAH or other neurological dysfunctions related to cerebral hemorrhage.
Journal ArticleDOI
Aspirin in retrieving the inactivated catalase to active form: Displacement of one inhibitor with a protective agent.
Yunes Panahi,Reza Yekta,Gholamreza Dehghan,Samaneh Rashtbari,Behzad Baradaran,Nematollah Jonaidi Jafari,Ali Akbar Moosavi-Movahedi +6 more
TL;DR: Aspirin was considered as a protective agent to retrieve the inactivated catalase by farnesiferol C through displacement manner and catalytic assessment revealed that aspirin is able to remarkably retrieve the activity of FC-catalase from 4.2% to 98 ± 0.1% compare to the control sample.
Journal ArticleDOI
Enzyme-less amperometric sensor manufactured using a Nafion–LaNiO3 nanocomposite for hydrogen peroxide
TL;DR: In this article, an enzyme-less amperometric sensor based on Nafion (NF) and a LaNiO3 (LNO) nanocomposite was constructed for H2O2 detection.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.