Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Cholinesterase Inhibitors in Alzheimer's Disease
TL;DR: Data indicate that aminoacridines, as a class of compounds, have a statistically significant effect to diminish, slightly, some of the cognitive symptoms of Alzheimer's Disease, and encourage the use of drugs that will reverse multiple neurotransmitter deficits.
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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases.
Mehdi Sharifi-Rad,Nanjangud V. Anil Kumar,Paolo Zucca,Elena Maria Varoni,Luciana Dini,Elisa Panzarini,Jovana Rajkovic,Patrick Valere Tsouh Fokou,Elena Azzini,Ilaria Peluso,Abhay Prakash Mishra,Manisha Nigam,Youssef El Rayess,Marc El Beyrouthy,Letizia Polito,Marcello Iriti,Natália Martins,Miquel Martorell,Anca Oana Docea,William N. Setzer,Daniela Calina,William C. Cho,Javad Sharifi-Rad +22 more
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
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Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe)
TL;DR: It is hoped that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.
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Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Qingzheng Kang,Chunxue Yang +1 more
TL;DR: The abnormalities correlated with oxidative stress provide multiple potential therapeutic targets to develop safe and effective treatments for diabetic retinopathy and are summarized.
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Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
TL;DR: Understanding the spatiotemporal availability of iron and the role of iron in generating ROS will provide clues for the suppression of ROS and cytotoxic redox-active iron and enable us to find novel therapeutic targets for various diseases.
References
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Journal ArticleDOI
Disturbed Copper Bioavailability in Alzheimer's Disease
TL;DR: It is demonstrated that there is an apparent disturbance in metal homeostasis in AD and more research is urgently needed to understand how this disturbance can be addressed therapeutically.
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Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling
TL;DR: Loss-of-function studies demonstrate that knockdown of Srx in poorly differentiated colorectal cancer cells not only leads to the inhibition of colony formation and cell invasion in vitro, but also reduces tumor xenograft growth and represses metastasis to distal organs in a mouse orthotopic implantation model.
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Changes in intracellular redox status influence multidrug resistance in gastric adenocarcinoma cells.
TL;DR: Variation in the intracellular redox status may be closely correlated with MDR and may provide a valuable basic strategy for anticancer therapy.
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HSP90 and its inhibitors.
Huifang Hao,Yoshio Naomoto,Xiaohong Bao,Nobuyuki Watanabe,Kazufumi Sakurama,Kazuhiro Noma,Takayuki Motoki,Yasuko Tomono,Takuya Fukazawa,Yasuhiro Shirakawa,Tomoki Yamatsuji,Junji Matsuoka,Munenori Takaoka +12 more
TL;DR: The HSP90 molecular chaperone family is highly conserved and expressed in various organisms ranging from prokaryotes to eukaryotes and plays an important role in the progression of malignant disease.
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Differences in peripheral oxidative stress markers in Alzheimer's disease, vascular dementia and mixed dementia patients.
Hirokuni Hatanaka,Haruo Hanyu,Raita Fukasawa,Kentaro Hirao,Soichiro Shimizu,Hidekazu Kanetaka,Toshihiko Iwamoto +6 more
TL;DR: It is determined whether the possible roles of oxidative stress differ in the pathophysiology and cognitive decline of Alzheimer's disease, vascular dementia (VaD) and mixed Alzheimer's/vascular dementia (MD).