Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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How do plants defend themselves against pathogens-Biochemical mechanisms and genetic interventions
Simardeep Kaur,Mahesh Kumar Samota,M. I. Choudhary,Mukesh Choudhary,Abhay K. Pandey,Anshu Sharma,Julie Thakur +6 more
TL;DR: In this paper , the authors discuss the valuable information for understanding the biochemical response mechanism of plants to cope with pathogens and genomics-metabolomics-based sustainable development of pathogen proof cultivars along with knowledge gaps and future perspectives to enhance sustainable agricultural production.
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Anticancer natural medicines: An overview of cell signaling and other targets of anticancer phytochemicals.
Muhammad Furqan Akhtar,Ammara Saleem,Azhar Rasul,Mirza Muhammad Faran Ashraf Baig,May Bin-Jumah,Mohamed M. Abdel Daim +5 more
TL;DR: A wide array of phytochemicals has been pharmacologically evaluated for their chemo-preventive and chemotherapeutic potential for several decades and their mode of action is focused on.
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Enriched environment prevents oxidative stress in zebrafish submitted to unpredictable chronic stress.
Matheus Marcon,Ricieri Mocelin,Adrieli Sachett,Anna Maria Siebel,Ana Paula Herrmann,Angelo Luis Stapassoli Piato +5 more
TL;DR: The characterization of the effects of UCS protocol is expanded by assessing parameters of oxidative status in the zebrafish brain and reveal that EE protects against the oxidative stress induced by chronic stress.
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Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases.
Pengwei Li,Ming Xian Chang +1 more
TL;DR: In this article, the effects of pattern recognition receptors (PRRs) from the Toll-like (TLRs), the retinoic acid-induced gene I (RIG-I)-like receptors (RLRs) and the NOD-like receptor (NLRs) are summarized.
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Bakuchiol Attenuates Oxidative Stress and Neuron Damage by Regulating Trx1/TXNIP and the Phosphorylation of AMPK After Subarachnoid Hemorrhage in Mice.
Haixiao Liu,Wei Guo,Hao Guo,Lei Zhao,Liang Yue,Xia Li,Dayun Feng,Jianing Luo,Xun Wu,Wenxing Cui,Yan Qu +10 more
TL;DR: Bak attenuates EBI after SAH by alleviating BBB disruption, oxidative stress, and apoptosis via regulating Trx1/TXNIP expression and the phosphorylation of AMPK.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.