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Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Potential of phenolic compounds in Ligustrum robustum (Rxob.) Blume as antioxidant and lipase inhibitors: Multi-spectroscopic methods and molecular docking.
TL;DR: Wang et al. as discussed by the authors evaluated the inhibitory effect and mechanism of L. robustum (Rxob.) Blume extract (LRE) on pancreatic lipase and showed that LRE exhibits significant antioxidant activities for scavenging free radicals and hydrogen peroxide, inhibiting lipid peroxidation and providing strong reducing power.
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Fluorescence study of the effect of the oxidized phospholipids on amyloid fibril formation by the apolipoprotein A-I N-terminal fragment
Kateryna Vus,Mykhailo Girych,Valeriya Trusova,Galyna Gorbenko,Paavo K.J. Kinnunen,Chiharu Mizuguchi,Hiroyuki Saito +6 more
TL;DR: The ability of PazePC to inhibit 1-83/G26R aggregation was explained by the protein-lipid electrostatic interactions, which either stabilize the α-helical structure of the membrane-associated 1- 83/G 26R or facilitate the protein solubilization by the detergent micelles.
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Klotho inhibits H 2 O 2 -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression.
TL;DR: It is found that Klotho inhibits H2O2-induced oxidative stress and apoptosis in PDLSCs by regulating UCP2 expression, a novel discovery that may provide a potential target for chronic periodontitis treatment.
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The protective effect of glutaredoxin 1/DJ-1/HSP70 signaling in renal tubular epithelial cells injury induced by ischemia.
TL;DR: Overall, this study showed that GRX1 minimizes cell injury and apoptosis in HK‐2 cells under OGD conditions via regulation of DJ‐1 and HSP70 expression and removes the constraints imposed on ROS level, LDH leakage, and caspase‐3 activity.
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Resveratrol prevents steroid-induced osteonecrosis of the femoral head via miR-146a modulation
Kai Nan,Jun-peng Pei,Lihong Fan,Yuan-Kai Zhang,Xin Zhang,Kang Liu,Zhibin Shi,Xiaoqian Dang,Kunzheng Wang +8 more
TL;DR: In this article, the authors investigated the possible use of resveratrol (Res) to reverse abnormal osteogenesis/osteoclastogenesis activity that occurs during femoral head osteonecrosis and to explore the detailed mechanisms.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.