Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Cholinesterase Inhibitors in Alzheimer's Disease
TL;DR: Data indicate that aminoacridines, as a class of compounds, have a statistically significant effect to diminish, slightly, some of the cognitive symptoms of Alzheimer's Disease, and encourage the use of drugs that will reverse multiple neurotransmitter deficits.
Journal ArticleDOI
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases.
Mehdi Sharifi-Rad,Nanjangud V. Anil Kumar,Paolo Zucca,Elena Maria Varoni,Luciana Dini,Elisa Panzarini,Jovana Rajkovic,Patrick Valere Tsouh Fokou,Elena Azzini,Ilaria Peluso,Abhay Prakash Mishra,Manisha Nigam,Youssef El Rayess,Marc El Beyrouthy,Letizia Polito,Marcello Iriti,Natália Martins,Miquel Martorell,Anca Oana Docea,William N. Setzer,Daniela Calina,William C. Cho,Javad Sharifi-Rad +22 more
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
Journal ArticleDOI
Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe)
TL;DR: It is hoped that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.
Journal ArticleDOI
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Qingzheng Kang,Chunxue Yang +1 more
TL;DR: The abnormalities correlated with oxidative stress provide multiple potential therapeutic targets to develop safe and effective treatments for diabetic retinopathy and are summarized.
Journal ArticleDOI
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
TL;DR: Understanding the spatiotemporal availability of iron and the role of iron in generating ROS will provide clues for the suppression of ROS and cytotoxic redox-active iron and enable us to find novel therapeutic targets for various diseases.
References
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Journal ArticleDOI
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.
Christine Marzano,Valentina Gandin,Alessandra Folda,Guido Scutari,Alberto Bindoli,Maria Pia Rigobello +5 more
TL;DR: The effects of auranofin, a gold(I) compound clinically used as an antirheumatic agent, on cisplatin-sensitive (2008) and-resistant (C13*) cancer cells were studied and its action is particularly marked in C13* cells, indicating that no cross-resistance occurs.
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Antioxidant Therapy: Current Status and Future Prospects
TL;DR: Recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed and some suggestions are provided to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.
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Fenton chemistry in biology and medicine
TL;DR: Accumulated evidence shows that both hydroxyl radical and ferryl [Fe(IV)=O]2+ can be formed under a variety of Fenton and Fenton-like reactions.
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Therapeutic strategies for Alzheimer's disease in clinical trials
TL;DR: Current directions in the search for novel, potentially effective agents for the treatment of AD are presented, as well as selected promising treatment strategies.
Journal ArticleDOI
Metal dyshomeostasis and oxidative stress in Alzheimer's disease.
TL;DR: This review discusses oxidative/nitrosative stress in Alzheimer's disease with a focus on the role that metals play in this process, and discusses metal binding compounds that are designed to cross the blood brain barrier and restore metal homeostasis as potential Alzheimer’s disease therapeutics.