Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Curcumin encapsulated zein/caseinate-alginate nanoparticles: Release and antioxidant activity under in vitro simulated gastrointestinal digestion
TL;DR: Curcumin-loaded zein/sodium caseinate-alginate nanoparticles were successfully fabricated using a pH-shift method/electrostatic deposition method in this article , where the curcumin was an amorphous, and the content in the nanoparticles was around 4.9%.
Journal ArticleDOI
Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain
Damilare Rotimi,Goodnews Mavoghenegbero Ben-Goru,Ikponmwosa Owen Evbuomwan,Tobiloba Christiana Elebiyo,Mohammed Alorabi,Abdullah Farasani,Gaber El-Saber Batiha,Oluyomi Stephen Adeyemi +7 more
TL;DR: Results showed that the V. amygdalina and Z. officinale tea infusions have favorable antioxidant properties in the rat brain, and these findings contribute to deepening the understanding of the health-promoting effects of V. Officinale root and Vernonia amygdAlina leaf.
Book ChapterDOI
Antioxidative response mechanisms of nanocelluloses and nanohydrogels matrices: a review
TL;DR: In this article, a review of nanocellulose and nanohydrogel matrices have been reported to have impact on oxidative stress in cell-free and cellular environments, taking advantage of the antioxidative stress and other properties offered by these two materials, the current report is aimed to provide the in-depth understanding of the biological studies with significant findings.
Journal ArticleDOI
Cassia auriculata and its role in infection / inflammation: A close look on future drug discovery
TL;DR: In this article , the phytoconstituents responsible for various properties such as antioxidant, anti-microbial and anti-diabetic activities were identified from C. auriculata Linn.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.