Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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The effect of Luteolin on DNA damage mediated by a copper catalyzed Fenton reaction
TL;DR: In this article , the effect of copper-II-chelation by luteolin on DNA damage via the Cu-Fenton reaction was studied, and the effect was more pronounced compared to quercetin and kaempferol.
Journal ArticleDOI
An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects.
TL;DR: This review attempts to provide a summary of the main molecular mechanisms involved in flavonoid radio-protective effects and can help to optimize their effects in radioprotection procedures.
Journal ArticleDOI
Cerium Oxide-Decorated γ-Fe2O3 Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress.
Maksym Moskvin,Irena Markova,Hana Malinska,Denisa Miklankova,Martina Hüttl,Olena Oliyarnyk,Ognen Pop-Georgievski,Alexander Zhigunov,Eduard Petrovský,Daniel Horák +9 more
TL;DR: In the animal model γ-Fe2O3/CeOx@PEG2,000 nanoparticles effectively scavenged radicals due to the presence of cerium oxide, in turn decreasing oxidative stress, and may have the potential to reduce disorders associated with oxidative stress and inflammation.
Journal ArticleDOI
Albumin mediated reactive oxygen species scavenging and targeted delivery of methotrexate for rheumatoid arthritis therapy
TL;DR: Wang et al. as mentioned in this paper used superoxide dismutase (SOD) and human serum albumin (HSA) to form HSA-SOD-MTX nanoparticles.
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Sleep, physical activity, sedentary behavior, and risk of incident dementia: A prospective cohort study of 431,924 UK Biobank participants
Shu-Yi Huang,Yu-zhu Li,Ya-Ru Zhang,Yu-Yuan Huang,Bang-Sheng Wu,Wei Zhang,Yue-Ting Deng,Shi-Dong Chen,Xiao-Yu He,Shu-Fen Chen,Qiang-Li Dong,Can Zhang,Ren-Jie Chen,John Suckling,Edmund T. Rolls,Jianfeng Feng,W. Cheng,Jin Yu +17 more
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.