Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Cholinesterase Inhibitors in Alzheimer's Disease
TL;DR: Data indicate that aminoacridines, as a class of compounds, have a statistically significant effect to diminish, slightly, some of the cognitive symptoms of Alzheimer's Disease, and encourage the use of drugs that will reverse multiple neurotransmitter deficits.
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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases.
Mehdi Sharifi-Rad,Nanjangud V. Anil Kumar,Paolo Zucca,Elena Maria Varoni,Luciana Dini,Elisa Panzarini,Jovana Rajkovic,Patrick Valere Tsouh Fokou,Elena Azzini,Ilaria Peluso,Abhay Prakash Mishra,Manisha Nigam,Youssef El Rayess,Marc El Beyrouthy,Letizia Polito,Marcello Iriti,Natália Martins,Miquel Martorell,Anca Oana Docea,William N. Setzer,Daniela Calina,William C. Cho,Javad Sharifi-Rad +22 more
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
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Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe)
TL;DR: It is hoped that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.
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Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Qingzheng Kang,Chunxue Yang +1 more
TL;DR: The abnormalities correlated with oxidative stress provide multiple potential therapeutic targets to develop safe and effective treatments for diabetic retinopathy and are summarized.
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Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
TL;DR: Understanding the spatiotemporal availability of iron and the role of iron in generating ROS will provide clues for the suppression of ROS and cytotoxic redox-active iron and enable us to find novel therapeutic targets for various diseases.
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Chemotherapy-Associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness
TL;DR: The use of anti-oxidants during chemotherapy may enhance therapy by reducing the generation of oxidative stress-induced aldehydes, which may inhibit drug-induced apoptosis and diminish the efficacy of the treatment.
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Nox Enzymes, ROS, and Chronic Disease: An Example of Antagonistic Pleiotropy
TL;DR: It is proposed that these pathological roles of Nox enzymes can be understood in terms of antagonistic pleiotropy: genes that confer a reproductive advantage early in life can have harmful effects late in life, particularly in chronic diseases associated with an aging population.
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Free radicals and antioxidants - quo vadis?
TL;DR: This brief commentary highlights in broad terms the current status of the redox biology field and the major challenges it faces in the next decade.
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Vitamin C: antioxidant or pro-oxidant in vivo?
TL;DR: Ascorbic acid has a multiplicity of antioxidant properties, but it can exert pro-oxidant effects in vitro, usually by interaction with transition metal ions, and it is as yet uncertain that these pro-oxide effects have any biological relevance.
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Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.
TL;DR: The results uncover a striking similarity in apoptosis regulation between neurons and cancer cells and provide insight into an adaptive advantage offered by the Warburg effect for cancer cell evasion of apoptosis and for long-term neuronal survival.