Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Cholinesterase Inhibitors in Alzheimer's Disease
TL;DR: Data indicate that aminoacridines, as a class of compounds, have a statistically significant effect to diminish, slightly, some of the cognitive symptoms of Alzheimer's Disease, and encourage the use of drugs that will reverse multiple neurotransmitter deficits.
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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases.
Mehdi Sharifi-Rad,Nanjangud V. Anil Kumar,Paolo Zucca,Elena Maria Varoni,Luciana Dini,Elisa Panzarini,Jovana Rajkovic,Patrick Valere Tsouh Fokou,Elena Azzini,Ilaria Peluso,Abhay Prakash Mishra,Manisha Nigam,Youssef El Rayess,Marc El Beyrouthy,Letizia Polito,Marcello Iriti,Natália Martins,Miquel Martorell,Anca Oana Docea,William N. Setzer,Daniela Calina,William C. Cho,Javad Sharifi-Rad +22 more
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
Journal ArticleDOI
Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe)
TL;DR: It is hoped that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.
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Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Qingzheng Kang,Chunxue Yang +1 more
TL;DR: The abnormalities correlated with oxidative stress provide multiple potential therapeutic targets to develop safe and effective treatments for diabetic retinopathy and are summarized.
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Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
TL;DR: Understanding the spatiotemporal availability of iron and the role of iron in generating ROS will provide clues for the suppression of ROS and cytotoxic redox-active iron and enable us to find novel therapeutic targets for various diseases.
References
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Journal ArticleDOI
Old and new acetylcholinesterase inhibitors for Alzheimer’s disease
Daniela Galimberti,Elio Scarpini +1 more
TL;DR: Despite many clinical trials with novel AChEIs carried out after the registration of those currently used to treat mild to moderate AD, none so far has been successful in a Phase III trial and marketed.
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Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies
TL;DR: The study indicates that Srx is a functionally significant target of AP-1 blockade that may have value in cancer prevention or treatment and screening of patient tissues by tissue microarray reveals elevated Srx expression in several types of human skin cancers.
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Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease.
Carlos Opazo,Sandra Luza,Victor L. Villemagne,Irene Volitakis,Christopher C. Rowe,Kevin J. Barnham,Dorothea Strozyk,Colin L. Masters,Robert A. Cherny,Ashley I. Bush,Ashley I. Bush +10 more
TL;DR: The data support metallated Aβ species as the neuropharmacological target of CQ and indicate that this drug class may have potential as in vivo imaging agents for Alzheimer neuropathology.
Journal ArticleDOI
Vitamin Intake and Liver Cancer Risk: A Report From Two Cohort Studies in China
Wei Zhang,Xiao-Ou Shu,Honglan Li,Gong Yang,Hui Cai,Bu-Tian Ji,Jing Gao,Yu-Tang Gao,Wei Zheng,Yong-Bing Xiang +9 more
TL;DR: Dietary vitamin E intake, either from diet or supplements, may reduce the risk of liver cancer, and this association was consistent among participants with and without self-reported liver disease or a family history of Liver cancer.
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Measurement of cholinergic drug effects on memory in Alzheimer's disease.
TL;DR: Double-blind, placebo-controlled investigations of scopolamine, physostigmine, arecoline, and tetrahydroaminoacridine in normal adults and in dementia of the Alzheimer-type (DAT) were reviewed to determine the relative sensitivity of various assessment procedures in the measurement of drug effects.