Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer's disease
Yash Pal Singh,Gauri Shankar,Shagufta Jahan,Gourav Singh,Navneet Kumar,Atanu Barik,Prabhat Upadhyay,Lovejit Singh,Kajal Kamble,Gireesh Kumar Singh,Sanjay Tiwari,Prabha Garg,Sarika Gupta,Gyan Modi +13 more
TL;DR: In this article, a series of multifunctional cholinesterase (ChE) inhibitors were developed for the management of AD. But, the effect of substitution of phenylpiperazine ring with benzyl piperazine, increase in the linker length between FA and substituted phenyl ring, and replacement of indole moiety with tryptamine on this molecular template, three series of novel molecules were developed.
Sistema antioxidante enzimático en mujeres con diagnóstico de Atipias celulares y Neoplasia Intraepitelial Cervical grado I
Danay Heredia Ruiz,Manuela Herrera Martínez,Douglas Fernández Caraballo,Lázara Gladys López Ocampo,María Bárbara Gómez Monteagudo,Emilio Francisco González Rodríguez +5 more
TL;DR: Determinar el comportamiento del sistema enzimatico antioxidante en mujeres con atipia de celulas escamosas de significado indeterminado y neoplasia intraepitelial cervical grado I podria considerarse un cofactor importante in the progresion of las lesiones en el cervix uterino.
Journal ArticleDOI
Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for <i>In Vivo</i> Detection of Sessile Serrated Adenomas
TL;DR: In this paper , the binding partner of the peptide ligand, peroxiredoxin-1 (Prdx1), was found to be overexpressed on the membrane of cells with the BRAFV600E mutation, and this effect was dependent on oxidative stress.
Journal ArticleDOI
CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.
Kenta Kainoh,Ryo Takano,Motohiro Sekiya,Kenji Saito,Takehito Sugasawa,Yang Ma,Yuki Murayama,Yoko Sugano,Yoshinori Osaki,Hitoshi Iwasaki,Yoshinori Takeuchi,Naoya Yahagi,Hiroaki Suzuki,Takafumi Miyamoto,Yoshimi Nakagawa,Takashi Matsuzaka,Hitoshi Shimano +16 more
TL;DR: In this paper, C-terminal binding protein 2 (CtBP2), a transcriptional cofactor with redox-sensing capability, is an obligate partner of NRFs.
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The profiles of durian (Durio zibethinus Murr.) shell phenolics and their antioxidant effects on H2O2-treated HepG2 cells as well as the metabolites and organ distribution in rats.
Yangzheng He,Li Peng,Hua Xiong,Wenqiang Liu,Hua Zhang,Xin Peng,Xue-Mei Zhu,Fang-Fei Guo,Yong Sun +8 more
TL;DR: In this paper , a total of 17 compounds were identified in durian shell extract (DSE) by using an ultra-high-performance liquid chromatography coupled with linear ion trap quadrupole Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MS/MS).
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.