Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Catalase immobilized Antimonene quantum dots used as an electrochemical biosensor for quantitative determination of H2O2 from CA-125 diagnosed ovarian Cancer samples
Batool Fatima,Dilshad Hussain,Shazia Bashir,Hafiza Tanzilla Hussain,Rashida Aslam,Rahat Nawaz,Hafiza Nadia Rashid,Nabila Bashir,Saadat Majeed,Muhammad Naeem Ashiq,Muhammad Najam-ul-Haq +10 more
TL;DR: Results demonstrate that concentration of H2O2 increases with increasing levels of CA125 in serum, and Cat@AMQDs-GCE shows good selectivity in presence of ascorbic acid, dopamine, leucine and glucose.
Journal ArticleDOI
Regulation of redox balance using a biocompatible nanoplatform enhances phototherapy efficacy and suppresses tumor metastasis.
Qunying Jiang,Min Pan,Jialing Hu,Junlin Sun,Lei Fan,Zhiqiao Zou,Jianshuang Wei,Xiaoquan Yang,Xiaoqing Liu +8 more
TL;DR: Following the glutathione-stimulated photosensitizer release to generate exogenous ROS, polydopamine eliminates the endogenous ROS scavenging system through depleting the primary antioxidant, thus amplifying the phototherapy and effectively suppressing tumor growth in vitro and in vivo.
Journal ArticleDOI
How do plants defend themselves against pathogens-Biochemical mechanisms and genetic interventions
Simardeep Kaur,Mahesh Kumar Samota,M. I. Choudhary,Mukesh Choudhary,Abhay K. Pandey,Anshu Sharma,Julie Thakur +6 more
TL;DR: In this paper , the authors discuss the valuable information for understanding the biochemical response mechanism of plants to cope with pathogens and genomics-metabolomics-based sustainable development of pathogen proof cultivars along with knowledge gaps and future perspectives to enhance sustainable agricultural production.
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Redox tolerance and metabolic reprogramming in solid tumors
TL;DR: Redox tolerance and metabolic reprogramming are interrelated, and that disruption of redox tolerance systems by transient exposure to either oxidative or antioxidative loading, or targeting metabolic rewiring by modulation of tumor glucose availability, controlling tumor/stroma interactions, etc. can be effective from a therapeutic standpoint.
Journal ArticleDOI
Total DNA Methylation Changes Reflect Random Oxidative DNA Damage in Gliomas
Anna-Maria Barciszewska,Małgorzata Giel-Pietraszuk,Patrick M. Perrigue,Mirosława Z. Naskręt-Barciszewska +3 more
TL;DR: 8-oxo-dG could also predict glioma malignancy grade and global DNA demethylation in cancer cells, and bolster previous findings, suggesting that spontaneously generated ROS react with m5C.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.