Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Cholinesterase Inhibitors in Alzheimer's Disease
TL;DR: Data indicate that aminoacridines, as a class of compounds, have a statistically significant effect to diminish, slightly, some of the cognitive symptoms of Alzheimer's Disease, and encourage the use of drugs that will reverse multiple neurotransmitter deficits.
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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases.
Mehdi Sharifi-Rad,Nanjangud V. Anil Kumar,Paolo Zucca,Elena Maria Varoni,Luciana Dini,Elisa Panzarini,Jovana Rajkovic,Patrick Valere Tsouh Fokou,Elena Azzini,Ilaria Peluso,Abhay Prakash Mishra,Manisha Nigam,Youssef El Rayess,Marc El Beyrouthy,Letizia Polito,Marcello Iriti,Natália Martins,Miquel Martorell,Anca Oana Docea,William N. Setzer,Daniela Calina,William C. Cho,Javad Sharifi-Rad +22 more
TL;DR: The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
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Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe)
TL;DR: It is hoped that this updated review paper will attract more attention to ginger and its further applications, including its potential to be developed into functional foods or nutraceuticals for the prevention and management of chronic diseases.
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Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Qingzheng Kang,Chunxue Yang +1 more
TL;DR: The abnormalities correlated with oxidative stress provide multiple potential therapeutic targets to develop safe and effective treatments for diabetic retinopathy and are summarized.
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Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
TL;DR: Understanding the spatiotemporal availability of iron and the role of iron in generating ROS will provide clues for the suppression of ROS and cytotoxic redox-active iron and enable us to find novel therapeutic targets for various diseases.
References
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Journal ArticleDOI
Prediction of individual response to anticancer therapy: historical and future perspectives.
TL;DR: Different currently used chemosensitivity assays including 2D and 3D cell culture models and several –omics approaches for the discovery of predictive biomarkers are presented and the potential of these assays and biomarkers to predict the clinical outcome of individual patients and future perspectives are discussed.
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Identifying, By First-Principles Simulations, Cu[Amyloid-β] Species Making Fenton-Type Reactions in Alzheimer’s Disease
TL;DR: The study gives a rationale for the Fenton-type reactivity of Cu-Aβ and how dimeric Cu(I)-Aβ could lead to a higher reactivity, which opens a new therapeutic angle of attack against Cu- aβ-based reactive oxygen species production.
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Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells
TL;DR: 2-methoxyestradiol inhibited the proliferation and induced apoptosis in human neuroblastoma SK-N-SH and SH-SY5Y cells and suggested that oxidative stress plays an important role in 2-ME-induced apoptotic death of human Neuroblastoma cells.
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7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment
Jan Korabecny,Martin Andrs,Eugenie Nepovimova,Rafael Dolezal,Katerina Babkova,Anna Horova,David Malinak,Eva Mezeiova,Lukas Gorecki,Vendula Sepsova,Martina Hrabinova,Ondrej Soukup,Daniel Jun,Kamil Kuca +13 more
TL;DR: Following the multi-target directed ligands (MTDLs) strategy, the synthesis, biological evaluation and docking studies for novel 7-methoxytacrine-p-anisidine hybrids designed to purposely target both cholinesterases and the amyloid cascade proved to be effective non-specific cholinersterase inhibitors showing non-competitive AChE inhibition patterns.
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Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach.
Michelle Kiebala,Jolanta Skalska,Carla Casulo,Paul S. Brookes,Derick R. Peterson,Shannon P. Hilchey,Yun Dai,Steven Grant,Sanjay B. Maggirwar,Steven H. Bernstein +9 more
TL;DR: It is suggested that AUR+BSO synergistically induces malignant B-cell death, a process mediated by dual inhibition of TrxR and NF-κB, and such an approach warrants further investigation in B- cell malignancies.