Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Homeostasis and dyshomeostasis of the retina
Chang-Jun Zhang,Zidan Jin +1 more
TL;DR: In this paper , a comprehensive understanding of the retinal homeostasis and dyshomeostasis will assist the development of treatment strategies for retinal degenerative diseases and open new avenues for clinical translation.
Dissertation
Perfil químico e atividades antioxidante, anti-inflamatória, antimutagênica e antimicrobiana do geoprópolis da abelha sem ferrão Melipona orbignyi
TL;DR: A composicao quimica do extrato hidroetanolico de geopropolis (EHGP) de Melipona orbignyi as discussed by the authors was determined by cromatografia liquida de alta performance acoplada ao detector de matriz de diodos e espectrometria de massa (HPLC-DAD-MS).
Journal ArticleDOI
Vanillic acid and vitamin C attenuated di-2-ethylhexyl phthalate-induced testicular toxicity in adult male rats
TL;DR: Vanillic acid and Vitamin C supplementation attenuated the toxic effects of DEHP on the testicular functions, morphology and semen characterization of the experimental adult male Wistar rats.
Journal ArticleDOI
Effects of Soybean Trypsin Inhibitor on Pancreatic Oxidative Damage of Mice at Different Growth Periods
TL;DR: In this article , the authors investigated the effect of soybean trypsin inhibitor (STI) intake on pancreatic injury and its mechanism of action, a five-week animal experiment was conducted, meanwhile, a weekly monitor on the degree of oxidation and antioxidant indexes in the serum and pancreas of the animals was carried out.
Journal ArticleDOI
Licochalcone B, a Natural Autophagic Agent for Alleviating Oxidative Stress-Induced Cell Death in Neuronal Cells and Caenorhabditis elegans Models
Li‐Li Qu,Jianhui Wu,Yong-qing Tang,Xiaoyun Yun,Hang Hong Lo,Lu Yu,Wenhua Li,An Guo Wu,Betty Yuen Kwan Law +8 more
TL;DR: LCB was confirmed to possess its anti-apoptotic effects in H2O2-induced cells through the induction of ATG7-dependent autophagy and the SIRT1/AMPK signaling pathway and suggested that LCB has potential neuroprotective effects on oxidative damage models via multiple protective pharmacological mechanisms.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.