Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
Reads0
Chats0
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
More filters
Journal ArticleDOI
Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells
Victoria Simões Bernardo,Flaviene Felix Torres,C. P. de Paula,João Pedro Maia de Oliveira da Silva,Eduardo Alves de Almeida,Anderson F. Cunha,Danilo Grünig Humberto da Silva +6 more
TL;DR: In this article , the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways was established.
Journal ArticleDOI
Screening of Antioxidant Activity of 20 Kinds of Mushrooms from Southwest of China
Dong-Hao He,Zhao-Hui Yu,Yi Huang +2 more
TL;DR: There was a correlation between antioxidant activity and total phenolic content and the reaction time of the DPPH test affected the free radical scavenging, which reflected the difference of the extract component would impact the test method.
Journal ArticleDOI
Characterization and Preliminary In Vitro Antioxidant Activity of a New Multidrug Formulation Based on the Co-Encapsulation of Rutin and the α-Acylamino-β-Lactone NAAA Inhibitor URB894 within PLGA Nanoparticles
TL;DR: In this article , a biodegradable and biocompatible polymeric matrix made up of poly(d,l-lactide-co-glycolide) (PLGA) was used for the simultaneous delivery of rutin and the (S)-N-(2-oxo-3-oxetanyl)biphenyl-4-carboxamide derivative (URB894).
Journal ArticleDOI
Antioxidant interactions among hydrophilic and lipophilic dietary phytochemicals based on inhibition of low-density lipoprotein and DNA damage.
TL;DR: This study provided a basis for antioxidant interactions among phytochemicals against ox-LDL and DNA damage in vivo and the choice of appropriate ratios and structures of hydrophilic and lipophilic phytochemicalicals should be considered in the diet and formulation of functional foods.
References
More filters
Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.