Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Antioxidant Capacity and NF-kB-Mediated Anti-Inflammatory Activity of Six Red Uruguayan Grape Pomaces
Hellen Daghero,Mariela Bollati-Fogolín,Eduardo Boido,Jorge Cantero,Mauricio Moncada-Basualto,Claudio Olea-Azar,Fabio Polticelli,Margot Paulino +7 more
TL;DR: In this paper, six Uruguayan red grape pomaces were evaluated in their phenolics composition, antioxidant capacity, and anti-inflammatory properties, and a molecular docking study was carried out to rationalize the experimental results allowing them to propose the proactive interaction between the NF-κB, the grape extracts phenols, and their putative antiinflammatory bioactivity.
Posted ContentDOI
Establishment of the trans-resveratrol-induced mouse pulmonary fibrosis model and its comparison with the bleomycin-induced model
Yiwen C,Chenzhong Z,Chunrui S,Hongsheng C,Shuyan W,Hongzhao Z,Shanshan L,qiaohui Z,Ruijuan D,GE Dong-yu,Xue Y,Lina L +11 more
TL;DR: Although the pathogenesis is not understood, the TR-induced PF model indicated that there may be a close relationship between PF and tumors and antitumor drugs, which requires further exploration.
Journal ArticleDOI
What We Know about Euterpe Genus and Neuroprotection: A Scoping Review
TL;DR: The Euterpe genus (mainly Euterp oleracea Martius, precatoria Martius and edulis Martius) has recently gained commercial and scientific notoriety due to the high nutritional value of its fruits, which are rich in polyphenols (phenolic acids and anthocyanins) and have potent antioxidant activity as discussed by the authors .
Journal ArticleDOI
Free Radicals and Actinobacteria as a Misexplored Goldmine of Antioxidant Compounds.
Thales Henrique B. de Oliveira,Norma Buarque de Gusmão,Leonor Alves de Oliveira da Silva,Luana Cassandra Breitenbach Barroso Coelho +3 more
TL;DR: In this paper, a review of the literature about Actinobacteria highlights an important capacity of producing natural antioxidants; however, there is a lack of in vivo studies of these isolated compounds.
Journal ArticleDOI
Multiple Metabolites Derived from Mushrooms and Their Beneficial Effect on Alzheimer’s Diseases
TL;DR: In this article , a review summarizes recent investigations of multiple constituents (carbohydrates, peptides, phenols, etc.) isolated from mushrooms to combat Alzheimer's disease, and the underlying molecular mechanisms of mushroom metabolites against AD are discussed.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.