Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Ethacridine Regulation of JAK/STAT/ERK Signaling Pathway in Colon Cancer Cells SW620: In vitro Approach
TL;DR: In this paper , the effect of ethacridine on colorectal cancer cell lines, SW620, via regulation of JAK/STAT/ERK signaling pathway was studied via DAPI and PI staining assays.
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Blackcurrant Incorporated Biofunctional Cookie Digesta Shows Chemical and Cellular Biological Activity Against Human Liver Cancer Cells, HepG2
Mofasser Hossain,Margaret A. Brennan,Susan L. Mason,Xinbo Guo,Xin-An Zeng,Charles S. Brennan +5 more
TL;DR: The exerted synergistic effects of this study suggest that there may be a new and effective option to prevent and control chronic diseases in human, as well as investigating the biofunctional potential of blackcurrant powder incorporated into wholemeal wheat and barley cookies in after simulated in vitro digestion.
Journal ArticleDOI
Dynamics of prooxidant and antioxidant homeostasis rates in patients with lichen ruber planus in the process of complex treatment
N.B. Brodovska,O.I. Denysenko +1 more
TL;DR: In this article, the dynamics of the parameters of prooxidant antioxidant homeostasis and those of endogenous intoxication in patients with lichen ruber planus (LRP) when used in the complex treatment of antioxidant and laser therapy were analyzed.
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Selection of High Functional Red Paprika (Capsicum annuum L.) Germplasms by Antioxidant Activity, Polyphenol Content, and Red Pigment Amount
Journal ArticleDOI
A review of nutritional implications of bioactive compounds of Ginger (Zingiber officinale Roscoe), their biological activities and nano-formulations
TL;DR: The use of nano-formulations of bioactive compounds of ginger will be a more effective strategy in drug delivery and bring ginger to the forefront of nutraceuticals for the treatment and/or prevention of various human health disorders.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.