Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Antioxidant Barrier and Oxidative Damage to Proteins, Lipids, and DNA/RNA in Adrenal Tumor Patients.
Barbara Choromańska,Piotr Myśliwiec,Tomasz Kozłowski,Magdalena Łuba,Piotr Wojskowicz,Jacek Dadan,Hanna Myśliwiec,Katarzyna Choromańska,Anna Gibała,Anna Starzyńska,Małgorzata Żendzian-Piotrowska,Anna Zalewska,Mateusz Maciejczyk +12 more
TL;DR: In this article, the authors assess redox balance, glutathione metabolism, and oxidative damage to RNA/DNA, proteins, and lipids in the plasma/serum and urine of patients with adrenal masses.
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Repurposing drugs to fight aging: The difficult path from bench to bedside
TL;DR: Recent advances and challenges in the field of repurposing widely used conventional pharmaceuticals to target the aging process are summarized and discussed.
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Antioxidant-Rich Woodfordia fruticosa Leaf Extract Alleviates Depressive-Like Behaviors and Impede Hyperglycemia.
Mohammed Abu Tayab,Kazi Ashfak Ahmed Chowdhury,Jabed,Syed Mohammed Tareq,A.T.M. Mostafa Kamal,Mohammad Nazmul Islam,A M Kafil Uddin,Mohammad Adil Hossain,Talha Bin Emran,Jesus Simal-Gandara +9 more
TL;DR: In this article, the authors examined the antioxidant, antidiabetic, and antidepressant potentials of methanol extract of W. fruticosa leaves through in vitro, in vivo, and computational models.
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Effects of Water Deficit Irrigation on Phenolic Composition and Antioxidant Activity of Monastrell Grapes under Semiarid Conditions.
Eva Pilar Pérez-Álvarez,Diego S. Intrigliolo,María Pilar Almajano,Pilar Rubio-Bretón,Teresa Garde-Cerdán +4 more
TL;DR: In this paper, the authors evaluated and compared the phenolic composition and antioxidant potential of Monastrell grapevines (Vitis vinifera L.) grown in eastern Spain were subjected to two water regime strategies: rainfed (non-irrigation) and RDI.
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Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Javad Sharifi-Rad,Simona Rapposelli,Simona Sestito,Jesús Herrera-Bravo,Alejandra Arancibia‐Díaz,Luis A. Salazar,Balakyz Yeskaliyeva,Ahmet Beyatli,Gerardo Leyva-Gómez,Carlos González-Contreras,Eda Sönmez Gürer,Miquel Martorell,Daniela Calina +12 more
TL;DR: The results of the studies showed that the use of phytochemicals against AD has gained relevance due to their antioxidant, anti-neuroinflammatory,Anti-amyloid, and anti-hyperphosphorylation properties of Tau protein.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.