Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Extraction of Antioxidants from Winemaking Byproducts: Effect of the Solvent on Phenolic Composition, Antioxidant and Anti-Cholinesterase Activities, and Electrochemical Behaviour
María José Jara-Palacios,Sandra Gonçalves,Francisco J. Heredia,Dolores Hernanz,Anabela Romano +4 more
TL;DR: The findings indicate that winemaking byproducts represent a source of phenolic compounds with antioxidant and anti-cholinesterase activities and suggest that cyclic voltammetry is a promising technique to evaluate the phenolic extraction process from these byproducts.
Journal ArticleDOI
Medicinal Plants from Brazilian Cerrado: Antioxidant and Anticancer Potential and Protection against Chemotherapy Toxicity
José Tarcisio Giffoni de Carvalho,Débora da Silva Baldivia,Daniel Ferreira Leite,Laura Costa Alves de Araújo,Priscilla Pereira de Toledo Espindola,Kátia Ávila Antunes,Paola dos Santos da Rocha,Kely de Picoli Souza,Edson Lucas dos Santos +8 more
TL;DR: The antioxidant properties of extracts obtained from medicinal plants from the Brazilian Cerrado and the cell death profile induced by each of these extracts in malignant cells are discussed and perspectives for future therapeutic approaches are focused on.
Journal ArticleDOI
Approaching reactive species in the frame of their clinical significance: A toxicological appraisal
TL;DR: It is concluded that reactive species do not seem to exert clinical significance, which means that they lack a measurable cause-effect relation with chronic diseases.
Journal ArticleDOI
Evaluation of the anti-bacterial activity of methanolic extract of Chlorella vulgaris Beyerinck [Beijerinck] with special reference to antioxidant modulation
Biswajita Pradhan,Srimanta Patra,Soumya Ranjan Dash,Rabindra Nayak,Chhandashree Behera,Mrutyunjay Jena +5 more
TL;DR: In this article, the assessment of antioxidant potential as well as free radical scavenging activity such as DPPH, hydroxyl radical, hydrogen peroxide, and superoxide anion radical assay of Chlorella vulgaris Beyerinck [Beijerinck] (BUACC25) isolated from marine habitat have been investigated.
Journal ArticleDOI
Nepeta curviflora essential oil: Phytochemical composition, antioxidant, anti-proliferative and anti-migratory efficacy against cervical cancer cells, and α-glucosidase, α-amylase and porcine pancreatic lipase inhibitory activities
TL;DR: In this paper, the phytochemical composition of Nepeta curviflora Boiss essential oil was qualitatively and quantitatively determined utilizing gas chromatography-mass spectrometry technique.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.